Effects of transient hypotension on the structure and function of rat kidney

Jeffrey I. Kreisberg, Ruth Ellen Bulger, Benjamin F. Trump, Raymond B Nagle

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The immediate effects on renal structure and function of 60 or 90 min of hypotension and the effects of one to four days of recovery were studied in the rat. An initial diuresis occurred during the first day after hypotension, followed by decreased urine volumes. Along with the diuresis, the animals secreted a hypo-osmolar urine for two days following hypotension, which returned to a normal concentration at three days. Twentyfour hour urine sodium excretion was depressed during the first and second days after hypotension while potassium excretion was no different from that of control animals. The morphologic alterations of tissue fixed immediately following 60 and 90 min of hypotension were greatest in the pars recta of the proximal tubule but were also seen focally in the pars convoluta. The cellular changes included dilated endoplasmic reticulum, clumped nuclear chromatin, swollen mitochondria with small flocculent densities, and the formation of multivesicular bodies. One day after the hypotension, cell death and necrosis were observed extensively in the pars recta. This study describes an experimental model for the study of the renal effects of hypovolemic shock in rats.

Original languageEnglish (US)
Pages (from-to)121-133
Number of pages13
JournalVirchows Archiv B Cell Pathology
Volume22
Issue number1
DOIs
StatePublished - Dec 1976
Externally publishedYes

Fingerprint

Hypotension
Kidney
Diuresis
Urine
Rectum
Multivesicular Bodies
Endoplasmic Reticulum
Chromatin
Shock
Potassium
Mitochondria
Cell Death
Theoretical Models
Necrosis
Sodium

Keywords

  • Hypovolemia
  • Renal ultrastructure
  • Shock

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Effects of transient hypotension on the structure and function of rat kidney. / Kreisberg, Jeffrey I.; Bulger, Ruth Ellen; Trump, Benjamin F.; Nagle, Raymond B.

In: Virchows Archiv B Cell Pathology, Vol. 22, No. 1, 12.1976, p. 121-133.

Research output: Contribution to journalArticle

Kreisberg, Jeffrey I. ; Bulger, Ruth Ellen ; Trump, Benjamin F. ; Nagle, Raymond B. / Effects of transient hypotension on the structure and function of rat kidney. In: Virchows Archiv B Cell Pathology. 1976 ; Vol. 22, No. 1. pp. 121-133.
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