Effects of tumor status on the regulation of natural killer cell activity by tumor-associated fetal antigens

Kevin T. Hogan, David T. Harris, Steven R. Plunkett, Milton Raben, Arthur H. Hale, Donald L. Evans

Research output: Contribution to journalArticlepeer-review

Abstract

In the present study we examined the effects of a tumor-associated fetal antigen (TAFA-II) on the activity of natural killer (NK) cells isolated from human cancer patients. TAFA-II suppressed the NK cell response of some patients, and the level of suppression appeared to be independent of tumor type or stage of cancer therapy. No significant correlations were found between lymphocyte, neutrophil, monocyte, or eosinophil populations and TAFA-induced suppression of NK cell activity. TAFA-II effects were also not attributable to Ia+ cells or to OKT3, OKT4, or OKT8 positive cells. This work confirmed results obtained in the rat model, in which suppression appeared to be directly mediated on the NK cell.

Original languageEnglish (US)
Pages (from-to)353-357
Number of pages5
JournalJournal of Biological Response Modifiers
Volume4
Issue number4
StatePublished - Aug 1985
Externally publishedYes

Keywords

  • Cancer
  • Natural killer cells
  • Tumor-associated fetal antigen

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Cancer Research

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