Effects of weight reduction on cellular cation metabolism and vascular resistance

David B. Jacobs, James R. Sowers, Ammar Hmeidan, Tushar Niyogi, Lori Simpson, Paul R Standley

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The early stages of weight loss are associated with a reduction in blood pressure, and the mechanisms mediating this reduction remain unclear. Platelet free calcium levels, [Ca<sup>2+</sup>]i» have been reported to be elevated in essential hypertension and to decrease with pharmacological treatment of the hypertension. In the current study, 18 obese subjects had measurements of blood pressure, forearm blood flow, forearm vascular resistance, and both basal platelet [Ca<sup>2+</sup>]i and [Ca<sup>2+</sup>]i responses to vasopressin during 12 weeks on a very low calorie (3,360 kj, or 800 kcal) diet. Weight reduction was associated with reduction in mean arterial blood pressure at 3-4 weeks. There were associated reductions in forearm vascular resistance and platelet [Ca<sup>2+</sup>]i as well as increases in forearm blood flow at 3-4 weeks of the diet. Increased forearm blood flow was correlated with weight loss. Vasopressin-induced platelet [Ca<sup>2+</sup>]| responses increased, which correlated with the reduction in mean arterial pressure at 7-8 weeks of weight loss. Assuming that platelet [Ca<sup>2+</sup>]j metabolism reflects vascular smooth muscle cell [Ca<sup>2+</sup>h metabolism, the data suggest that blood pressure reduction after weight loss may be related to reduced vascular smooth muscle cell [Ca<sup>2+</sup>]|. The reason for the increased vasopressin-induced [Ca<sup>2+</sup>]<inf>s</inf> after weight reduction is unclear. (Hypertension 1993;21:308-314)

Original languageEnglish (US)
Pages (from-to)308-314
Number of pages7
JournalHypertension
Volume21
Issue number3
StatePublished - 1993
Externally publishedYes

Fingerprint

Vascular Resistance
Cations
Weight Loss
Forearm
Blood Platelets
Vasopressins
Arterial Pressure
Blood Pressure
Vascular Smooth Muscle
Smooth Muscle Myocytes
Diet
Hypertension
Pharmacology
Calcium

Keywords

  • Calcium
  • Vascular resistance
  • Weight loss

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Jacobs, D. B., Sowers, J. R., Hmeidan, A., Niyogi, T., Simpson, L., & Standley, P. R. (1993). Effects of weight reduction on cellular cation metabolism and vascular resistance. Hypertension, 21(3), 308-314.

Effects of weight reduction on cellular cation metabolism and vascular resistance. / Jacobs, David B.; Sowers, James R.; Hmeidan, Ammar; Niyogi, Tushar; Simpson, Lori; Standley, Paul R.

In: Hypertension, Vol. 21, No. 3, 1993, p. 308-314.

Research output: Contribution to journalArticle

Jacobs, DB, Sowers, JR, Hmeidan, A, Niyogi, T, Simpson, L & Standley, PR 1993, 'Effects of weight reduction on cellular cation metabolism and vascular resistance', Hypertension, vol. 21, no. 3, pp. 308-314.
Jacobs DB, Sowers JR, Hmeidan A, Niyogi T, Simpson L, Standley PR. Effects of weight reduction on cellular cation metabolism and vascular resistance. Hypertension. 1993;21(3):308-314.
Jacobs, David B. ; Sowers, James R. ; Hmeidan, Ammar ; Niyogi, Tushar ; Simpson, Lori ; Standley, Paul R. / Effects of weight reduction on cellular cation metabolism and vascular resistance. In: Hypertension. 1993 ; Vol. 21, No. 3. pp. 308-314.
@article{620fdb4ba6954ef7b6d1b2cf17a8da59,
title = "Effects of weight reduction on cellular cation metabolism and vascular resistance",
abstract = "The early stages of weight loss are associated with a reduction in blood pressure, and the mechanisms mediating this reduction remain unclear. Platelet free calcium levels, [Ca2+]i» have been reported to be elevated in essential hypertension and to decrease with pharmacological treatment of the hypertension. In the current study, 18 obese subjects had measurements of blood pressure, forearm blood flow, forearm vascular resistance, and both basal platelet [Ca2+]i and [Ca2+]i responses to vasopressin during 12 weeks on a very low calorie (3,360 kj, or 800 kcal) diet. Weight reduction was associated with reduction in mean arterial blood pressure at 3-4 weeks. There were associated reductions in forearm vascular resistance and platelet [Ca2+]i as well as increases in forearm blood flow at 3-4 weeks of the diet. Increased forearm blood flow was correlated with weight loss. Vasopressin-induced platelet [Ca2+]| responses increased, which correlated with the reduction in mean arterial pressure at 7-8 weeks of weight loss. Assuming that platelet [Ca2+]j metabolism reflects vascular smooth muscle cell [Ca2+h metabolism, the data suggest that blood pressure reduction after weight loss may be related to reduced vascular smooth muscle cell [Ca2+]|. The reason for the increased vasopressin-induced [Ca2+]s after weight reduction is unclear. (Hypertension 1993;21:308-314)",
keywords = "Calcium, Vascular resistance, Weight loss",
author = "Jacobs, {David B.} and Sowers, {James R.} and Ammar Hmeidan and Tushar Niyogi and Lori Simpson and Standley, {Paul R}",
year = "1993",
language = "English (US)",
volume = "21",
pages = "308--314",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Effects of weight reduction on cellular cation metabolism and vascular resistance

AU - Jacobs, David B.

AU - Sowers, James R.

AU - Hmeidan, Ammar

AU - Niyogi, Tushar

AU - Simpson, Lori

AU - Standley, Paul R

PY - 1993

Y1 - 1993

N2 - The early stages of weight loss are associated with a reduction in blood pressure, and the mechanisms mediating this reduction remain unclear. Platelet free calcium levels, [Ca2+]i» have been reported to be elevated in essential hypertension and to decrease with pharmacological treatment of the hypertension. In the current study, 18 obese subjects had measurements of blood pressure, forearm blood flow, forearm vascular resistance, and both basal platelet [Ca2+]i and [Ca2+]i responses to vasopressin during 12 weeks on a very low calorie (3,360 kj, or 800 kcal) diet. Weight reduction was associated with reduction in mean arterial blood pressure at 3-4 weeks. There were associated reductions in forearm vascular resistance and platelet [Ca2+]i as well as increases in forearm blood flow at 3-4 weeks of the diet. Increased forearm blood flow was correlated with weight loss. Vasopressin-induced platelet [Ca2+]| responses increased, which correlated with the reduction in mean arterial pressure at 7-8 weeks of weight loss. Assuming that platelet [Ca2+]j metabolism reflects vascular smooth muscle cell [Ca2+h metabolism, the data suggest that blood pressure reduction after weight loss may be related to reduced vascular smooth muscle cell [Ca2+]|. The reason for the increased vasopressin-induced [Ca2+]s after weight reduction is unclear. (Hypertension 1993;21:308-314)

AB - The early stages of weight loss are associated with a reduction in blood pressure, and the mechanisms mediating this reduction remain unclear. Platelet free calcium levels, [Ca2+]i» have been reported to be elevated in essential hypertension and to decrease with pharmacological treatment of the hypertension. In the current study, 18 obese subjects had measurements of blood pressure, forearm blood flow, forearm vascular resistance, and both basal platelet [Ca2+]i and [Ca2+]i responses to vasopressin during 12 weeks on a very low calorie (3,360 kj, or 800 kcal) diet. Weight reduction was associated with reduction in mean arterial blood pressure at 3-4 weeks. There were associated reductions in forearm vascular resistance and platelet [Ca2+]i as well as increases in forearm blood flow at 3-4 weeks of the diet. Increased forearm blood flow was correlated with weight loss. Vasopressin-induced platelet [Ca2+]| responses increased, which correlated with the reduction in mean arterial pressure at 7-8 weeks of weight loss. Assuming that platelet [Ca2+]j metabolism reflects vascular smooth muscle cell [Ca2+h metabolism, the data suggest that blood pressure reduction after weight loss may be related to reduced vascular smooth muscle cell [Ca2+]|. The reason for the increased vasopressin-induced [Ca2+]s after weight reduction is unclear. (Hypertension 1993;21:308-314)

KW - Calcium

KW - Vascular resistance

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=0027463749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027463749&partnerID=8YFLogxK

M3 - Article

VL - 21

SP - 308

EP - 314

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 3

ER -