Effects of weight reduction on circulating parathyroid hypertensive factor levels

J. R. Sowers, Paul R Standley, R. Z. Lewanczuk, P. K T Pang

Research output: Contribution to journalArticle

Abstract

This study evaluated changes in parathyroid hypertensive factor (PHF) in 18 obese individuals. PHF levels were measured prior to the onset of a low calorie diet (800 kcal/day), and at 3-4 weeks, 7-8 weeks, and 11-12 weeks after initiation of the diet. Blood pressure, forearm vascular resistance, and platelet intracellular calcium ([Ca2+](i)) levels were also measured at the same time. Although blood pressure, vascular resistance, and platelet [Ca2+](i) decreased significantly in association with the low-calorie diet and weight reduction. PHF levels did not change significantly during the 12- week diet period. We conclude that PHF levels do not track with reductions in blood pressure, vascular resistance, and platelet [Ca2+](i) levels in obese individuals.

Original languageEnglish (US)
JournalJournal of Cardiovascular Pharmacology
Volume23
Issue numberSUPPL. 2
StatePublished - 1994
Externally publishedYes

Fingerprint

Weight Loss
Vascular Resistance
Caloric Restriction
Blood Platelets
Blood Pressure
Diet
Forearm
Calcium
parathyroid hypertensive factor

Keywords

  • Parathyroid hypertensive factor
  • Weight

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Effects of weight reduction on circulating parathyroid hypertensive factor levels. / Sowers, J. R.; Standley, Paul R; Lewanczuk, R. Z.; Pang, P. K T.

In: Journal of Cardiovascular Pharmacology, Vol. 23, No. SUPPL. 2, 1994.

Research output: Contribution to journalArticle

@article{c2209299bf16483bb93dece93e47e65b,
title = "Effects of weight reduction on circulating parathyroid hypertensive factor levels",
abstract = "This study evaluated changes in parathyroid hypertensive factor (PHF) in 18 obese individuals. PHF levels were measured prior to the onset of a low calorie diet (800 kcal/day), and at 3-4 weeks, 7-8 weeks, and 11-12 weeks after initiation of the diet. Blood pressure, forearm vascular resistance, and platelet intracellular calcium ([Ca2+](i)) levels were also measured at the same time. Although blood pressure, vascular resistance, and platelet [Ca2+](i) decreased significantly in association with the low-calorie diet and weight reduction. PHF levels did not change significantly during the 12- week diet period. We conclude that PHF levels do not track with reductions in blood pressure, vascular resistance, and platelet [Ca2+](i) levels in obese individuals.",
keywords = "Parathyroid hypertensive factor, Weight",
author = "Sowers, {J. R.} and Standley, {Paul R} and Lewanczuk, {R. Z.} and Pang, {P. K T}",
year = "1994",
language = "English (US)",
volume = "23",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams and Wilkins",
number = "SUPPL. 2",

}

TY - JOUR

T1 - Effects of weight reduction on circulating parathyroid hypertensive factor levels

AU - Sowers, J. R.

AU - Standley, Paul R

AU - Lewanczuk, R. Z.

AU - Pang, P. K T

PY - 1994

Y1 - 1994

N2 - This study evaluated changes in parathyroid hypertensive factor (PHF) in 18 obese individuals. PHF levels were measured prior to the onset of a low calorie diet (800 kcal/day), and at 3-4 weeks, 7-8 weeks, and 11-12 weeks after initiation of the diet. Blood pressure, forearm vascular resistance, and platelet intracellular calcium ([Ca2+](i)) levels were also measured at the same time. Although blood pressure, vascular resistance, and platelet [Ca2+](i) decreased significantly in association with the low-calorie diet and weight reduction. PHF levels did not change significantly during the 12- week diet period. We conclude that PHF levels do not track with reductions in blood pressure, vascular resistance, and platelet [Ca2+](i) levels in obese individuals.

AB - This study evaluated changes in parathyroid hypertensive factor (PHF) in 18 obese individuals. PHF levels were measured prior to the onset of a low calorie diet (800 kcal/day), and at 3-4 weeks, 7-8 weeks, and 11-12 weeks after initiation of the diet. Blood pressure, forearm vascular resistance, and platelet intracellular calcium ([Ca2+](i)) levels were also measured at the same time. Although blood pressure, vascular resistance, and platelet [Ca2+](i) decreased significantly in association with the low-calorie diet and weight reduction. PHF levels did not change significantly during the 12- week diet period. We conclude that PHF levels do not track with reductions in blood pressure, vascular resistance, and platelet [Ca2+](i) levels in obese individuals.

KW - Parathyroid hypertensive factor

KW - Weight

UR - http://www.scopus.com/inward/record.url?scp=0028329559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028329559&partnerID=8YFLogxK

M3 - Article

C2 - 7518544

AN - SCOPUS:0028329559

VL - 23

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - SUPPL. 2

ER -