Effects of weight reduction on circulating parathyroid hypertensive factor levels

J. R. Sowers, P. R. Standley, R. Z. Lewanczuk, P. K.T. Pang

Research output: Contribution to journalArticle

Abstract

This study evaluated changes in parathyroid hypertensive factor (PHF) in 18 obese individuals. PHF levels were measured prior to the onset of a low calorie diet (800 kcal/day), and at 3-4 weeks, 7-8 weeks, and 11-12 weeks after initiation of the diet. Blood pressure, forearm vascular resistance, and platelet intracellular calcium ([Ca2+](i)) levels were also measured at the same time. Although blood pressure, vascular resistance, and platelet [Ca2+](i) decreased significantly in association with the low-calorie diet and weight reduction. PHF levels did not change significantly during the 12- week diet period. We conclude that PHF levels do not track with reductions in blood pressure, vascular resistance, and platelet [Ca2+](i) levels in obese individuals.

Original languageEnglish (US)
Pages (from-to)S35-S37
JournalJournal of Cardiovascular Pharmacology
Volume23
Issue numberSUPPL. 2
StatePublished - Apr 26 1994
Externally publishedYes

Keywords

  • Parathyroid hypertensive factor
  • Weight

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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