This study evaluated changes in parathyroid hypertensive factor (PHF) in 18 obese individuals. PHF levels were measured prior to the onset of a low calorie diet (800 kcal/day), and at 3-4 weeks, 7-8 weeks, and 11-12 weeks after initiation of the diet. Blood pressure, forearm vascular resistance, and platelet intracellular calcium ([Ca2+](i)) levels were also measured at the same time. Although blood pressure, vascular resistance, and platelet [Ca2+](i) decreased significantly in association with the low-calorie diet and weight reduction. PHF levels did not change significantly during the 12- week diet period. We conclude that PHF levels do not track with reductions in blood pressure, vascular resistance, and platelet [Ca2+](i) levels in obese individuals.
|Original language||English (US)|
|Journal||Journal of Cardiovascular Pharmacology|
|Issue number||SUPPL. 2|
|State||Published - Apr 26 1994|
- Parathyroid hypertensive factor
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine