Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis

Janet L Funk, Jennifer B. Frye, Janice N. Oyarzo, Nesrin Kuscuoglu, Jonathan Wilson, Gwen McCaffrey, Gregory Stafford, Guanjie Chen, Robert Clark Lantz, Shivanand D. Jolad, Aniko M. Sólyom, Pawel R Kiela, Barbara N. Timmermann

Research output: Contribution to journalArticle

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Abstract

Objective. Scientific evidence is lacking for the antiarthritic efficacy of turmeric dietary supplements that are being promoted for arthritis treatment. Therefore, we undertook studies to determine the antiarthritic efficacy and mechanism of action of a well-characterized turmeric extract using an animal model of rheumatoid arthritis (RA). Methods. The composition of commercial turmeric dietary supplements was determined by high-performance liquid chromatography. A curcuminoid-containing turmeric extract similar in composition to these supplements was isolated and administered intraperitoneally to female Lewis rats prior to or after the onset of streptococcal cell wall-induced arthritis. Efficacy in preventing joint swelling and destruction was determined clinically, histologically, and by measurement of bone mineral density. Mechanism of action was elucidated by analysis of turmeric's effect on articular transcription factor activation, microarray analysis of articular gene expression, and verification of the physiologic effects of alterations in gene expression. Results. A turmeric fraction depleted of essential oils profoundly inhibited joint inflammation and periarticular joint destruction in a dose-dependent manner. In vivo treatment prevented local activation of NF-κB and the subsequent expression of NF-κB-regulated genes mediating joint inflammation and destruction, including chemokines, cyclooxygenase 2, and RANKL. Consistent with these findings, inflammatory cell influx, joint levels of prostaglandin E2, and periarticular osteoclast formation were inhibited by turmeric extract treatment. Conclusion. These translational studies demonstrate in vivo efficacy and identify a mechanism of action for a well-characterized turmeric extract that supports further clinical evaluation of turmeric dietary supplements in the treatment of RA.

Original languageEnglish (US)
Pages (from-to)3452-3464
Number of pages13
JournalArthritis and Rheumatism
Volume54
Issue number11
DOIs
StatePublished - Nov 2006

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Curcuma
Experimental Arthritis
Joints
Dietary Supplements
Arthritis
Rheumatoid Arthritis
Inflammation
Activation Analysis
Gene Expression
Osteoclasts
Cyclooxygenase 2
Volatile Oils
Microarray Analysis
Chemokines
Dinoprostone
Bone Density
Cell Wall
Transcriptional Activation
Transcription Factors
Animal Models

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Funk, J. L., Frye, J. B., Oyarzo, J. N., Kuscuoglu, N., Wilson, J., McCaffrey, G., ... Timmermann, B. N. (2006). Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis and Rheumatism, 54(11), 3452-3464. https://doi.org/10.1002/art.22180

Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. / Funk, Janet L; Frye, Jennifer B.; Oyarzo, Janice N.; Kuscuoglu, Nesrin; Wilson, Jonathan; McCaffrey, Gwen; Stafford, Gregory; Chen, Guanjie; Lantz, Robert Clark; Jolad, Shivanand D.; Sólyom, Aniko M.; Kiela, Pawel R; Timmermann, Barbara N.

In: Arthritis and Rheumatism, Vol. 54, No. 11, 11.2006, p. 3452-3464.

Research output: Contribution to journalArticle

Funk, JL, Frye, JB, Oyarzo, JN, Kuscuoglu, N, Wilson, J, McCaffrey, G, Stafford, G, Chen, G, Lantz, RC, Jolad, SD, Sólyom, AM, Kiela, PR & Timmermann, BN 2006, 'Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis', Arthritis and Rheumatism, vol. 54, no. 11, pp. 3452-3464. https://doi.org/10.1002/art.22180
Funk, Janet L ; Frye, Jennifer B. ; Oyarzo, Janice N. ; Kuscuoglu, Nesrin ; Wilson, Jonathan ; McCaffrey, Gwen ; Stafford, Gregory ; Chen, Guanjie ; Lantz, Robert Clark ; Jolad, Shivanand D. ; Sólyom, Aniko M. ; Kiela, Pawel R ; Timmermann, Barbara N. / Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. In: Arthritis and Rheumatism. 2006 ; Vol. 54, No. 11. pp. 3452-3464.
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