Efficacy of ambruticin analogs in a murine model of coccidioidomycosis

Lisa F. Shubitz, John N. Galgiani, Zong Qiang Tian, Ziyang Zhong, Pieter Timmermans, Leonard Katz

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.

Original languageEnglish (US)
Pages (from-to)3467-3469
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number10
DOIs
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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