Efficacy of combination therapy with insulin and oral hypoglycemic agents in patients with type II diabetes during a 1-year period

Robert P. Mozersky, Hitendra Patel, Vijay K. Bahl, Sachin Bahl, William Mook

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

In this retrospective study, the authors assess the efficacy of combined insulin and oral hypoglycemic agents (OHAs) in controlling glycemic levels, as well as lipid levels and insulin requirements, in 48 patients with type H diabetes mellitus during a 1-year period. Thirty-two of these patients had secondary failure to an OHA (group 1). Sixteen patients (group 2) were taking high doses of insulin alone. Overall, 64.6% of all the patients responded to the combination therapy and insulin at 6 months. Response was defined as a decrease in hemoglobin A(1c) of more than 0.5%. At 12 months, 50% of these patients continued to respond to this regimen. No significant differences were seen in the patients' total cholesterol and triglyceride levels between responders and nonresponders in each group. After 1 year of combination OHA and insulin therapy, 50% of the patients showed a 21.4% reduction in their daily insulin dose.

Original languageEnglish (US)
Pages (from-to)346-351
Number of pages6
JournalJournal of the American Osteopathic Association
Volume96
Issue number6
DOIs
StatePublished - Jan 1 1996

Keywords

  • Type II diabetes mellitus
  • glucose control
  • insulin therapy
  • oral hypoglycemic agents

ASJC Scopus subject areas

  • Complementary and alternative medicine

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