Abstract
In this retrospective study, the authors assess the efficacy of combined insulin and oral hypoglycemic agents (OHAs) in controlling glycemic levels, as well as lipid levels and insulin requirements, in 48 patients with type H diabetes mellitus during a 1-year period. Thirty-two of these patients had secondary failure to an OHA (group 1). Sixteen patients (group 2) were taking high doses of insulin alone. Overall, 64.6% of all the patients responded to the combination therapy and insulin at 6 months. Response was defined as a decrease in hemoglobin A(1c) of more than 0.5%. At 12 months, 50% of these patients continued to respond to this regimen. No significant differences were seen in the patients' total cholesterol and triglyceride levels between responders and nonresponders in each group. After 1 year of combination OHA and insulin therapy, 50% of the patients showed a 21.4% reduction in their daily insulin dose.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 346-351 |
| Number of pages | 6 |
| Journal | Journal of the American Osteopathic Association |
| Volume | 96 |
| Issue number | 6 |
| State | Published - 1996 |
| Externally published | Yes |
Fingerprint
Keywords
- glucose control
- insulin therapy
- oral hypoglycemic agents
- Type II diabetes mellitus
ASJC Scopus subject areas
- Complementary and alternative medicine
Cite this
Efficacy of combination therapy with insulin and oral hypoglycemic agents in patients with type II diabetes during a 1-year period. / Mozersky, Robert P.; Patel, Hitendra -; Bahl, Vijay K.; Bahl, Sachin; Mook, William.
In: Journal of the American Osteopathic Association, Vol. 96, No. 6, 1996, p. 346-351.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Efficacy of combination therapy with insulin and oral hypoglycemic agents in patients with type II diabetes during a 1-year period
AU - Mozersky, Robert P.
AU - Patel, Hitendra -
AU - Bahl, Vijay K.
AU - Bahl, Sachin
AU - Mook, William
PY - 1996
Y1 - 1996
N2 - In this retrospective study, the authors assess the efficacy of combined insulin and oral hypoglycemic agents (OHAs) in controlling glycemic levels, as well as lipid levels and insulin requirements, in 48 patients with type H diabetes mellitus during a 1-year period. Thirty-two of these patients had secondary failure to an OHA (group 1). Sixteen patients (group 2) were taking high doses of insulin alone. Overall, 64.6% of all the patients responded to the combination therapy and insulin at 6 months. Response was defined as a decrease in hemoglobin A(1c) of more than 0.5%. At 12 months, 50% of these patients continued to respond to this regimen. No significant differences were seen in the patients' total cholesterol and triglyceride levels between responders and nonresponders in each group. After 1 year of combination OHA and insulin therapy, 50% of the patients showed a 21.4% reduction in their daily insulin dose.
AB - In this retrospective study, the authors assess the efficacy of combined insulin and oral hypoglycemic agents (OHAs) in controlling glycemic levels, as well as lipid levels and insulin requirements, in 48 patients with type H diabetes mellitus during a 1-year period. Thirty-two of these patients had secondary failure to an OHA (group 1). Sixteen patients (group 2) were taking high doses of insulin alone. Overall, 64.6% of all the patients responded to the combination therapy and insulin at 6 months. Response was defined as a decrease in hemoglobin A(1c) of more than 0.5%. At 12 months, 50% of these patients continued to respond to this regimen. No significant differences were seen in the patients' total cholesterol and triglyceride levels between responders and nonresponders in each group. After 1 year of combination OHA and insulin therapy, 50% of the patients showed a 21.4% reduction in their daily insulin dose.
KW - glucose control
KW - insulin therapy
KW - oral hypoglycemic agents
KW - Type II diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=0029934310&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029934310&partnerID=8YFLogxK
M3 - Article
C2 - 8690621
AN - SCOPUS:0029934310
VL - 96
SP - 346
EP - 351
JO - The Journal of the American Osteopathic Association
JF - The Journal of the American Osteopathic Association
SN - 0098-6151
IS - 6
ER -