Modeling and Simulation (M&S) is an increasingly important tool in product life cycle engineering. Contractually demanded by many government programs, M&S is usable in the early stages of product functional and operational conceptualization as well as manufacturing process analysis, optimization and management. The application of M&S as a support tool in mission support (logistics) management has lagged behind that of design engineering and manufacturing process analysis and optimization. One reason is that the DoD has historically provided all logistics and mission support services. This trend is changing. Post acquisition mission support management programs have been identified by DoD and industry decision makers as a positive discriminating factor in the source selection decision. This paper presents a review of M&S technology and tools and suggestions of how M&S can be applied in support of proposal capture, program management and mission support for defense programs.