Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Nikkomycin Z (NikZ) is a chitin synthase inhibitor with antifungal efficacy against Coccidioides spp. and other endemic fungi. Dogs suffer a rate and range of natural coccidioidomycosis similar to humans and were considered an excellent model for initially testing NikZ against naturally acquired disease. Twelve dogs with coccidioidal pneumonia that had been present for an average of three months were treated with 250 mg (5-15 kg) or 500 mg (> 15-30 kg) twice daily for 60 days. Nine dogs completed the course of treatment and seven dogs had improvement in disease based on radiographs, clinicopathological parameters, physical examination findings, and subjective assessment by owners; three dogs had resolution or near resolution of disease. Based on this small study, NikZ shows efficacy to treat naturally acquired coccidioidomycosis and merits further development for trials in humans.

Original languageEnglish (US)
Pages (from-to)747-754
Number of pages8
JournalMedical Mycology
Volume51
Issue number7
DOIs
StatePublished - Oct 2013

Fingerprint

nikkomycins
coccidioidomycosis
Coccidioidomycosis
Dogs
dogs
Coccidioides
Chitin Synthase
chitin synthase
clinical examination
pneumonia
Physical Examination
Pneumonia
Fungi
nikkomycin
fungi

Keywords

  • Antifungal
  • Chitin synthase inhibitor
  • Coccidioides
  • Dogs
  • Nikkomycin Z

ASJC Scopus subject areas

  • veterinary(all)
  • Infectious Diseases

Cite this

Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs. / Shubitz, Lisa; Roy, Michael E.; Nix, David E.; Galgiani, John N.

In: Medical Mycology, Vol. 51, No. 7, 10.2013, p. 747-754.

Research output: Contribution to journalArticle

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