Efficacy of Nikkomycin Z for respiratory coccidioidomycosis in naturally infected dogs

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15 Scopus citations

Abstract

Nikkomycin Z (NikZ) is a chitin synthase inhibitor with antifungal efficacy against Coccidioides spp. and other endemic fungi. Dogs suffer a rate and range of natural coccidioidomycosis similar to humans and were considered an excellent model for initially testing NikZ against naturally acquired disease. Twelve dogs with coccidioidal pneumonia that had been present for an average of three months were treated with 250 mg (5-15 kg) or 500 mg (> 15-30 kg) twice daily for 60 days. Nine dogs completed the course of treatment and seven dogs had improvement in disease based on radiographs, clinicopathological parameters, physical examination findings, and subjective assessment by owners; three dogs had resolution or near resolution of disease. Based on this small study, NikZ shows efficacy to treat naturally acquired coccidioidomycosis and merits further development for trials in humans.

Original languageEnglish (US)
Pages (from-to)747-754
Number of pages8
JournalMedical mycology
Volume51
Issue number7
DOIs
StatePublished - Oct 2013

Keywords

  • Antifungal
  • Chitin synthase inhibitor
  • Coccidioides
  • Dogs
  • Nikkomycin Z

ASJC Scopus subject areas

  • Infectious Diseases

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