Efficacy of perfluorobutane as a phase-change contrast agent for low-energyultrasonic imaging

Paul S. Sheeran, Vincent P. Wong, Ryan J. McFarland, William D. Ross, Steven G. Feingold, Terry O Matsunaga, Paul A. Dayton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Most gas-filled ultrasound contrast agents are produced range of severalmicrons in diameter, which limits them to flow within intravascular space. Onemechanism proposed to produce extravascular imaging agents is acoustic dropletvaporization. Liquid perfluorocarbon droplets can be manufactured in thesub-micron range and can then passively diffuse through leaky tumor vasculature.It is hypothesized that once extravasated, these droplets could be converted tomicrobubbles in the micron range through additional energy input in the form ofultrasound, resulting in enhanced imaging contrast. Recent studies show currentformulations of phase-change contrast agents in the sub-micron range mayrequire substantial acoustic energy to vaporize, which increases the chance ofbioeffects. Thus, phase-change contrast agents with reduced acoustic activationenergies would have significant advantages. In this study, the generation andactivation of novel phase-change contrast agents formulated with perfluorobutaneis demonstrated. Perfluorobutane normally a gas at room temperature can beincorporated into metastable liquid sub-micron droplets with lipid encapsulationmethods. The resulting droplets are shown to be acoustically vaporizable withsubstantially less energy than other compounds proposed for phase-changecontrast agents such as perfluoropentane and perfluorohexane.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Ultrasonics Symposium
Pages904-907
Number of pages4
DOIs
StatePublished - 2010
Event2010 IEEE International Ultrasonics Symposium, IUS 2010 - San Diego, CA, United States
Duration: Oct 11 2010Oct 14 2010

Other

Other2010 IEEE International Ultrasonics Symposium, IUS 2010
CountryUnited States
CitySan Diego, CA
Period10/11/1010/14/10

Fingerprint

acoustics
liquids
gases
lipids
energy
tumors
room temperature

Keywords

  • contrast agent
  • perfluorocarbon
  • phase-change
  • tumor imaging
  • ultrasound
  • vaporization

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

Sheeran, P. S., Wong, V. P., McFarland, R. J., Ross, W. D., Feingold, S. G., Matsunaga, T. O., & Dayton, P. A. (2010). Efficacy of perfluorobutane as a phase-change contrast agent for low-energyultrasonic imaging. In Proceedings - IEEE Ultrasonics Symposium (pp. 904-907). [5935592] https://doi.org/10.1109/ULTSYM.2010.5935592

Efficacy of perfluorobutane as a phase-change contrast agent for low-energyultrasonic imaging. / Sheeran, Paul S.; Wong, Vincent P.; McFarland, Ryan J.; Ross, William D.; Feingold, Steven G.; Matsunaga, Terry O; Dayton, Paul A.

Proceedings - IEEE Ultrasonics Symposium. 2010. p. 904-907 5935592.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sheeran, PS, Wong, VP, McFarland, RJ, Ross, WD, Feingold, SG, Matsunaga, TO & Dayton, PA 2010, Efficacy of perfluorobutane as a phase-change contrast agent for low-energyultrasonic imaging. in Proceedings - IEEE Ultrasonics Symposium., 5935592, pp. 904-907, 2010 IEEE International Ultrasonics Symposium, IUS 2010, San Diego, CA, United States, 10/11/10. https://doi.org/10.1109/ULTSYM.2010.5935592
Sheeran PS, Wong VP, McFarland RJ, Ross WD, Feingold SG, Matsunaga TO et al. Efficacy of perfluorobutane as a phase-change contrast agent for low-energyultrasonic imaging. In Proceedings - IEEE Ultrasonics Symposium. 2010. p. 904-907. 5935592 https://doi.org/10.1109/ULTSYM.2010.5935592
Sheeran, Paul S. ; Wong, Vincent P. ; McFarland, Ryan J. ; Ross, William D. ; Feingold, Steven G. ; Matsunaga, Terry O ; Dayton, Paul A. / Efficacy of perfluorobutane as a phase-change contrast agent for low-energyultrasonic imaging. Proceedings - IEEE Ultrasonics Symposium. 2010. pp. 904-907
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