Efficacy of Purple Passion Fruit Peel Extract in Lowering Cardiovascular Risk Factors in Type 2 Diabetic Subjects

Naga N. Raju, Kodandarami K. Reddy, Krishna K. Kumari, Bhaskar B. Reddy, Dattatreya D. Rao, Damodar D. Reddy, Ronald Ross Watson

Research output: Contribution to journalArticle

5 Scopus citations


The clinical efficacy of purple passion fruit peel extract (a flavonoid-rich dietary supplement) in reducing cardiovascular risk factors in adult type 2 diabetic subjects was investigated in a randomized, double-blind, placebo-controlled trial. Forty-one subjects were randomly assigned to receive a daily dose of purple passion fruit (220 mg) or a matched placebo for 16 weeks. Body mass index, blood pressure, fasting and postprandial blood glucose, glycated hemoglobin, and lipid profile were determined at baseline and at monthly intervals. A significant reduction in systolic blood pressure and fasting blood glucose was observed following administration of purple passion fruit (P<.05). Purple passion fruit was well tolerated, and no adverse events were reported. These data suggest that purple passion fruit supplementation for 16 weeks in type 2 diabetics results in a significant reduction in systolic blood pressure and fasting blood glucose, indicating that purple passion fruit is safe and well tolerated by diabetics.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalJournal of Evidence-Based Complementary and Alternative Medicine
Issue number3
StatePublished - Jul 1 2013



  • antioxidants
  • blood glucose
  • blood pressure
  • flavonoid
  • human clinical trial
  • passion fruit peel extract
  • type 2 diabetes

ASJC Scopus subject areas

  • Complementary and alternative medicine

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