Efficacy of Purple Passion Fruit Peel Extract in Lowering Cardiovascular Risk Factors in Type 2 Diabetic Subjects

Naga N. Raju, Kodandarami K. Reddy, Krishna K. Kumari, Bhaskar B. Reddy, Dattatreya D. Rao, Damodar D. Reddy, Ronald R Watson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The clinical efficacy of purple passion fruit peel extract (a flavonoid-rich dietary supplement) in reducing cardiovascular risk factors in adult type 2 diabetic subjects was investigated in a randomized, double-blind, placebo-controlled trial. Forty-one subjects were randomly assigned to receive a daily dose of purple passion fruit (220 mg) or a matched placebo for 16 weeks. Body mass index, blood pressure, fasting and postprandial blood glucose, glycated hemoglobin, and lipid profile were determined at baseline and at monthly intervals. A significant reduction in systolic blood pressure and fasting blood glucose was observed following administration of purple passion fruit (P<.05). Purple passion fruit was well tolerated, and no adverse events were reported. These data suggest that purple passion fruit supplementation for 16 weeks in type 2 diabetics results in a significant reduction in systolic blood pressure and fasting blood glucose, indicating that purple passion fruit is safe and well tolerated by diabetics.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalJournal of Evidence-Based Complementary and Alternative Medicine
Volume18
Issue number3
DOIs
StatePublished - Jul 2013

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Fruit
Blood Pressure
Blood Glucose
Fasting
Placebos
Glycosylated Hemoglobin A
Dietary Supplements
Flavonoids
Body Mass Index
Lipids

Keywords

  • antioxidants
  • blood glucose
  • blood pressure
  • flavonoid
  • human clinical trial
  • passion fruit peel extract
  • type 2 diabetes

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Efficacy of Purple Passion Fruit Peel Extract in Lowering Cardiovascular Risk Factors in Type 2 Diabetic Subjects. / Raju, Naga N.; Reddy, Kodandarami K.; Kumari, Krishna K.; Reddy, Bhaskar B.; Rao, Dattatreya D.; Reddy, Damodar D.; Watson, Ronald R.

In: Journal of Evidence-Based Complementary and Alternative Medicine, Vol. 18, No. 3, 07.2013, p. 183-190.

Research output: Contribution to journalArticle

Raju, Naga N. ; Reddy, Kodandarami K. ; Kumari, Krishna K. ; Reddy, Bhaskar B. ; Rao, Dattatreya D. ; Reddy, Damodar D. ; Watson, Ronald R. / Efficacy of Purple Passion Fruit Peel Extract in Lowering Cardiovascular Risk Factors in Type 2 Diabetic Subjects. In: Journal of Evidence-Based Complementary and Alternative Medicine. 2013 ; Vol. 18, No. 3. pp. 183-190.
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