Efficient and stereoselective synthesis of novel cis-4-substituted proline analogues

Junyi Zhang, Wei Wang, Chiyi Xiong, Victor J. Hruby

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A series of novel cis-4-substituted proline analogues were designed and synthesized. Highly stereoselective alkylations at the γ-position of glutamic ester 2 were achieved, followed by reduction, mesylation, and cyclization to afford the title compounds 1 in good yields and high diastereoselectivity.

Original languageEnglish (US)
Pages (from-to)1413-1415
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number7
DOIs
StatePublished - Feb 10 2003

Keywords

  • Alkylation
  • Constrained amino acids
  • Proline

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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