Ejection fraction and heart rate correlate with diastolic peak filling rate at rest and during exercise

J. A. Bianco, A. W. Filiberti, S. P. Baker, M. A. King, L. A. Nalivaika, D. Leahey, P. W. Doherty, Joseph S Alpert

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Abstract

We investigated the independent variables correlating with the multigated radionuclide peak filling rate (PFR) at rest and during supine bicycle exercise in 20 normal individuals. Independent variables were systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), ejection fraction (LVEF), time to PFR (TPFR), peak ejection rate (PER) and time to PER (TPER). Fifteen subjects completed at least five stages of exercise at 25 watts each. Correlating independent variables were selected by a forward-backward stepwise multiple linear regression (BMDP2R). A partial correlation statistical program was also used to allow control of critical independent variables. The final regression equations were: a) resting state, PFR = -2.5 + 0.03HR + 0.05LVEF + 0.02SBP - 0.02DBP, and b) exercise state, PFR = -3.8 + 0.04HR + 0.08LVEF. All independent variables mentioned above correlated with PFR (simple correlations designated as zero partials). However, when LVEF and HR were held constant (second order partials), the correlation of PFR with any of the other independent variables disappeared. In summary, the radionuclide global LV PFR is predominantly correlated to LVEF and HR at rest and during exercise. These correlations should be considered when assessing exercise effects of disease states on PFR.

Original languageEnglish (US)
Pages (from-to)107-113
Number of pages7
JournalChest
Volume88
Issue number1
StatePublished - 1985
Externally publishedYes

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Heart Rate
Blood Pressure
Radioisotopes
Linear Models

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Bianco, J. A., Filiberti, A. W., Baker, S. P., King, M. A., Nalivaika, L. A., Leahey, D., ... Alpert, J. S. (1985). Ejection fraction and heart rate correlate with diastolic peak filling rate at rest and during exercise. Chest, 88(1), 107-113.

Ejection fraction and heart rate correlate with diastolic peak filling rate at rest and during exercise. / Bianco, J. A.; Filiberti, A. W.; Baker, S. P.; King, M. A.; Nalivaika, L. A.; Leahey, D.; Doherty, P. W.; Alpert, Joseph S.

In: Chest, Vol. 88, No. 1, 1985, p. 107-113.

Research output: Contribution to journalArticle

Bianco, JA, Filiberti, AW, Baker, SP, King, MA, Nalivaika, LA, Leahey, D, Doherty, PW & Alpert, JS 1985, 'Ejection fraction and heart rate correlate with diastolic peak filling rate at rest and during exercise', Chest, vol. 88, no. 1, pp. 107-113.
Bianco JA, Filiberti AW, Baker SP, King MA, Nalivaika LA, Leahey D et al. Ejection fraction and heart rate correlate with diastolic peak filling rate at rest and during exercise. Chest. 1985;88(1):107-113.
Bianco, J. A. ; Filiberti, A. W. ; Baker, S. P. ; King, M. A. ; Nalivaika, L. A. ; Leahey, D. ; Doherty, P. W. ; Alpert, Joseph S. / Ejection fraction and heart rate correlate with diastolic peak filling rate at rest and during exercise. In: Chest. 1985 ; Vol. 88, No. 1. pp. 107-113.
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T1 - Ejection fraction and heart rate correlate with diastolic peak filling rate at rest and during exercise

AU - Bianco, J. A.

AU - Filiberti, A. W.

AU - Baker, S. P.

AU - King, M. A.

AU - Nalivaika, L. A.

AU - Leahey, D.

AU - Doherty, P. W.

AU - Alpert, Joseph S

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N2 - We investigated the independent variables correlating with the multigated radionuclide peak filling rate (PFR) at rest and during supine bicycle exercise in 20 normal individuals. Independent variables were systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), ejection fraction (LVEF), time to PFR (TPFR), peak ejection rate (PER) and time to PER (TPER). Fifteen subjects completed at least five stages of exercise at 25 watts each. Correlating independent variables were selected by a forward-backward stepwise multiple linear regression (BMDP2R). A partial correlation statistical program was also used to allow control of critical independent variables. The final regression equations were: a) resting state, PFR = -2.5 + 0.03HR + 0.05LVEF + 0.02SBP - 0.02DBP, and b) exercise state, PFR = -3.8 + 0.04HR + 0.08LVEF. All independent variables mentioned above correlated with PFR (simple correlations designated as zero partials). However, when LVEF and HR were held constant (second order partials), the correlation of PFR with any of the other independent variables disappeared. In summary, the radionuclide global LV PFR is predominantly correlated to LVEF and HR at rest and during exercise. These correlations should be considered when assessing exercise effects of disease states on PFR.

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