Abstract
The mechanical properties of blood vessel walls are important determinants of physiology and pathology of the cardiovascular system. Acoustic imaging (B mode) is routinely used in a clinical setting to determine blood flow and wall distensibility. In this study scanning acoustic microscopy in vitro is used to determine spatially resolved tissue elastic properties. Broadband excitation of 30 MHz has been applied through scanning acoustic microscopy (SAM) for topographical imaging of swine thoracic aorta in reflection mode. Three differently treated tissue samples were investigated with SAM: a) treated with elastase to remove elastin, b) autoclaving for 5 hours to remove collagen and c) fresh controlled untreated sample as control. Experimental investigations are conducted for studying the contribution of individual protein components (elastin and collagen) to the material characteristics of the aortic wall. Conventional tensile testing has been conducted on the tissue samples to study the mechanical behavior. The mechanical properties measured by SAM and tensile testing show qualitative agreement.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
| Volume | 7984 |
| DOIs | |
| State | Published - 2011 |
| Event | Health Monitoring of Structural and Biological Systems 2011 - San Diego, CA, United States Duration: Mar 7 2011 → Mar 10 2011 |
Other
| Other | Health Monitoring of Structural and Biological Systems 2011 |
|---|---|
| Country | United States |
| City | San Diego, CA |
| Period | 3/7/11 → 3/10/11 |
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ASJC Scopus subject areas
- Applied Mathematics
- Computer Science Applications
- Electrical and Electronic Engineering
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
Cite this
Elastic characterization of swine aorta by scanning acoustic microscopy at 30 MHz. / Blase, Christopher; Shelke, Amit; Kundu, Tribikram; Bereiter-Hahn, Jürgen.
Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7984 2011. 79840Y.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Elastic characterization of swine aorta by scanning acoustic microscopy at 30 MHz
AU - Blase, Christopher
AU - Shelke, Amit
AU - Kundu, Tribikram
AU - Bereiter-Hahn, Jürgen
PY - 2011
Y1 - 2011
N2 - The mechanical properties of blood vessel walls are important determinants of physiology and pathology of the cardiovascular system. Acoustic imaging (B mode) is routinely used in a clinical setting to determine blood flow and wall distensibility. In this study scanning acoustic microscopy in vitro is used to determine spatially resolved tissue elastic properties. Broadband excitation of 30 MHz has been applied through scanning acoustic microscopy (SAM) for topographical imaging of swine thoracic aorta in reflection mode. Three differently treated tissue samples were investigated with SAM: a) treated with elastase to remove elastin, b) autoclaving for 5 hours to remove collagen and c) fresh controlled untreated sample as control. Experimental investigations are conducted for studying the contribution of individual protein components (elastin and collagen) to the material characteristics of the aortic wall. Conventional tensile testing has been conducted on the tissue samples to study the mechanical behavior. The mechanical properties measured by SAM and tensile testing show qualitative agreement.
AB - The mechanical properties of blood vessel walls are important determinants of physiology and pathology of the cardiovascular system. Acoustic imaging (B mode) is routinely used in a clinical setting to determine blood flow and wall distensibility. In this study scanning acoustic microscopy in vitro is used to determine spatially resolved tissue elastic properties. Broadband excitation of 30 MHz has been applied through scanning acoustic microscopy (SAM) for topographical imaging of swine thoracic aorta in reflection mode. Three differently treated tissue samples were investigated with SAM: a) treated with elastase to remove elastin, b) autoclaving for 5 hours to remove collagen and c) fresh controlled untreated sample as control. Experimental investigations are conducted for studying the contribution of individual protein components (elastin and collagen) to the material characteristics of the aortic wall. Conventional tensile testing has been conducted on the tissue samples to study the mechanical behavior. The mechanical properties measured by SAM and tensile testing show qualitative agreement.
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UR - http://www.scopus.com/inward/citedby.url?scp=79956190514&partnerID=8YFLogxK
U2 - 10.1117/12.881330
DO - 10.1117/12.881330
M3 - Conference contribution
AN - SCOPUS:79956190514
SN - 9780819485465
VL - 7984
BT - Proceedings of SPIE - The International Society for Optical Engineering
ER -