Elastic characterization of swine aorta by scanning acoustic microscopy at 30 MHz

Christopher Blase, Amit Shelke, Tribikram Kundu, Jürgen Bereiter-Hahn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The mechanical properties of blood vessel walls are important determinants of physiology and pathology of the cardiovascular system. Acoustic imaging (B mode) is routinely used in a clinical setting to determine blood flow and wall distensibility. In this study scanning acoustic microscopy in vitro is used to determine spatially resolved tissue elastic properties. Broadband excitation of 30 MHz has been applied through scanning acoustic microscopy (SAM) for topographical imaging of swine thoracic aorta in reflection mode. Three differently treated tissue samples were investigated with SAM: a) treated with elastase to remove elastin, b) autoclaving for 5 hours to remove collagen and c) fresh controlled untreated sample as control. Experimental investigations are conducted for studying the contribution of individual protein components (elastin and collagen) to the material characteristics of the aortic wall. Conventional tensile testing has been conducted on the tissue samples to study the mechanical behavior. The mechanical properties measured by SAM and tensile testing show qualitative agreement.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Volume7984
DOIs
StatePublished - 2011
EventHealth Monitoring of Structural and Biological Systems 2011 - San Diego, CA, United States
Duration: Mar 7 2011Mar 10 2011

Other

OtherHealth Monitoring of Structural and Biological Systems 2011
CountryUnited States
CitySan Diego, CA
Period3/7/113/10/11

Fingerprint

aorta
Aorta
swine
Microscopy
Scanning
Acoustics
elastin
microscopy
Elastin
scanning
acoustics
Tensile testing
collagens
Tissue
Collagen
autoclaving
Mechanical Properties
mechanical properties
Acoustic imaging
acoustic imaging

ASJC Scopus subject areas

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Blase, C., Shelke, A., Kundu, T., & Bereiter-Hahn, J. (2011). Elastic characterization of swine aorta by scanning acoustic microscopy at 30 MHz. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 7984). [79840Y] https://doi.org/10.1117/12.881330

Elastic characterization of swine aorta by scanning acoustic microscopy at 30 MHz. / Blase, Christopher; Shelke, Amit; Kundu, Tribikram; Bereiter-Hahn, Jürgen.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7984 2011. 79840Y.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Blase, C, Shelke, A, Kundu, T & Bereiter-Hahn, J 2011, Elastic characterization of swine aorta by scanning acoustic microscopy at 30 MHz. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 7984, 79840Y, Health Monitoring of Structural and Biological Systems 2011, San Diego, CA, United States, 3/7/11. https://doi.org/10.1117/12.881330
Blase C, Shelke A, Kundu T, Bereiter-Hahn J. Elastic characterization of swine aorta by scanning acoustic microscopy at 30 MHz. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7984. 2011. 79840Y https://doi.org/10.1117/12.881330
Blase, Christopher ; Shelke, Amit ; Kundu, Tribikram ; Bereiter-Hahn, Jürgen. / Elastic characterization of swine aorta by scanning acoustic microscopy at 30 MHz. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 7984 2011.
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