Elastic coiled-coils act as energy buffers in the ATP synthase

Sébastien Neukirch, Alain Goriely, Andrew Hausrath

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In the ATP synthase, transmission of energy from the membrane-embedded F0 sector to the catalytic F1 sector is accomplished by two stalks composed of coiled-coils. The great efficiency of the enzyme, despite the presence of a symmetry mismatch between the F1 and F0 sectors, suggests the involvement of elastic elements that store energy during the catalytic cycle. Here, the stalk subunits γ and b are investigated as the source of this elastic compliance using a continuum mechanical model of coiled-coils and energy arguments. The analysis shows that the compliance of both subunits is required for efficient energy transmission between F0 and F1. In addition, the predicted mechanical properties of coiled-coils in the ATP synthase suggest mechanisms whereby regulatory subunits influence the enzyme activity.

Original languageEnglish (US)
Pages (from-to)1064-1073
Number of pages10
JournalInternational Journal of Non-Linear Mechanics
Volume43
Issue number10
DOIs
StatePublished - Dec 2008

Fingerprint

Adenosinetriphosphate
ATP Synthase
Coil
Buffer
Sector
Compliance
Enzyme activity
Enzymes
Energy
Membranes
Energy Efficient
Mechanical properties
Mechanical Properties
Continuum
Membrane
Symmetry
Cycle
Model

Keywords

  • Coiled-coils
  • Energy transfer
  • Kirchhoff equations
  • Proteins
  • Rod

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Applied Mathematics

Cite this

Elastic coiled-coils act as energy buffers in the ATP synthase. / Neukirch, Sébastien; Goriely, Alain; Hausrath, Andrew.

In: International Journal of Non-Linear Mechanics, Vol. 43, No. 10, 12.2008, p. 1064-1073.

Research output: Contribution to journalArticle

Neukirch, Sébastien ; Goriely, Alain ; Hausrath, Andrew. / Elastic coiled-coils act as energy buffers in the ATP synthase. In: International Journal of Non-Linear Mechanics. 2008 ; Vol. 43, No. 10. pp. 1064-1073.
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