Elastic properties of a single-stranded charged homopolymeric ribonucleotide

Yeonee Seol, Gary M. Skinner, Koen Visscher

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

The elastic properties of poly(U), homopolymeric single-stranded RNA molecules that lack any base pairing and stacking interactions and conform to a random-coil structure were investigated. It was found that in its natural state under room temperature, both the base pairing and stacking interactions are negligible. Using a single-molecule stretching experiments, it was shown that the elastic properties could be described by a wormlike chain model for polymer elasticity rather than by a freely joined chain model used commonly for single-stranded DNA. It was also shown that at low [NA+], introduction of a scale-dependent persistence length is required to account for elastrostatic contributions.

Original languageEnglish (US)
Article number118102
Pages (from-to)118102-1-118102-4
JournalPhysical review letters
Volume93
Issue number11
DOIs
StatePublished - Sep 10 2004

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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