Elasticity and biochemistry of growth relate replication rate to cell length and cross-link density in rod-shaped bacteria

Akeisha M T Belgrave, Charles William Wolgemuth

Research output: Contribution to journalArticle

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Abstract

In rod-shaped bacteria, cell morphology is correlated with the replication rate. For a given species, cells that replicate faster are longer and have less cross-linked cell walls. Here, we propose a simple mechanochemical model that explains the dependence of cell length and cross-linking on the replication rate. Our model shows good agreement with existing experimental data and provides further evidence that cell wall synthesis is mediated by multienzyme complexes; however, our results suggest that these synthesis complexes only mediate glycan insertion and cross-link severing, whereas recross-linking is performed independently.

Original languageEnglish (US)
Pages (from-to)2607-2611
Number of pages5
JournalBiophysical Journal
Volume104
Issue number12
DOIs
StatePublished - Jun 18 2013

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Elasticity
Biochemistry
Bacteria
Cell Wall
Growth
Multienzyme Complexes
Polysaccharides

ASJC Scopus subject areas

  • Biophysics
  • Medicine(all)

Cite this

Elasticity and biochemistry of growth relate replication rate to cell length and cross-link density in rod-shaped bacteria. / Belgrave, Akeisha M T; Wolgemuth, Charles William.

In: Biophysical Journal, Vol. 104, No. 12, 18.06.2013, p. 2607-2611.

Research output: Contribution to journalArticle

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