Electrokinetic sample preparation for electrochemical assays: Towards point-of-care diagnosis of urinary tract infections

Mandy L.Y. Sin, Vincent Gau, Joseph C. Liao, Pak Kin Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

This paper presents a universal electrode approach which directly implements electrokinetic sample preparation on a SAM based electrochemical sensor for point-of-care diagnostics of urinary tract infections (UTI). Using uropathogenic E. coli clinical isolates as a model system, we demonstrate that on-chip electrokinetic sample preparation can accelerate the time-limiting incubation step for over 5-fold and enhance the amperometric signal of the strain specific 16S rRNA hybridization assay for one order of magnitude.

Original languageEnglish (US)
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages130-132
Number of pages3
StatePublished - 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume1

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/3/1010/7/10

Keywords

  • Electrochemical sensor
  • Electrokinetics
  • Point-of-care diagnosis
  • Sample preparation

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Sin, M. L. Y., Gau, V., Liao, J. C., & Wong, P. K. (2010). Electrokinetic sample preparation for electrochemical assays: Towards point-of-care diagnosis of urinary tract infections. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 130-132). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 1).