Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy

Dae Hyeong Kim, Roozbeh Ghaffari, Nanshu Lu, Shuodao Wang, Stephen P. Lee, Hohyun Keum, Robert D'Angelo, Lauren Klinker, Yewang Su, Chaofeng Lu, Yun Soung Kim, Abid Ameen, Yuhang Li, Yihui Zhang, Bassel De Graff, Yung Yu Hsu, ZhuangJian Liu, Jeremy Ruskin, Lizhi Xu, Chi LuFiorenzo G. Omenetto, Yonggang Huang, Moussa Mansour, Marvin J Slepian, John A. Rogers

Research output: Contribution to journalArticle

130 Citations (Scopus)

Abstract

Curved surfaces, complex geometries, and time-dynamic deformations of the heart create challenges in establishing intimate, non-constraining interfaces between cardiac structures and medical devices or surgical tools, particularly over large areas. We constructed large area designs for diagnostic and therapeutic stretchable sensor and actuator webs that conformally wrap the epicardium, establishing robust contact without sutures, mechanical fixtures, tapes, or surgical adhesives. These multifunctional web devices exploit open, mesh layouts and mount on thin, bio-resorbable sheets of silk to facilitate handling in a way that yields, after dissolution, exceptionally low mechanical moduli and thicknesses. In vivo studies in rabbit and pig animal models demonstrate the effectiveness of these device webs for measuring and spatially mapping temperature, electrophysiological signals, strain, and physical contact in sheet and balloon-based systems that also have the potential to deliver energy to perform localized tissue ablation.

Original languageEnglish (US)
Pages (from-to)19910-19915
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number49
DOIs
StatePublished - Dec 4 2012

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Equipment and Supplies
Surgical Tape
Silk
Pericardium
Sutures
Swine
Therapeutics
Animal Models
Rabbits
Temperature

Keywords

  • Cardiac electrophysiology
  • Flexible electronics
  • Implantable biomedical devices
  • Semiconductor nanomaterials
  • Stretchable electronics

ASJC Scopus subject areas

  • General

Cite this

Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy. / Kim, Dae Hyeong; Ghaffari, Roozbeh; Lu, Nanshu; Wang, Shuodao; Lee, Stephen P.; Keum, Hohyun; D'Angelo, Robert; Klinker, Lauren; Su, Yewang; Lu, Chaofeng; Kim, Yun Soung; Ameen, Abid; Li, Yuhang; Zhang, Yihui; De Graff, Bassel; Hsu, Yung Yu; Liu, ZhuangJian; Ruskin, Jeremy; Xu, Lizhi; Lu, Chi; Omenetto, Fiorenzo G.; Huang, Yonggang; Mansour, Moussa; Slepian, Marvin J; Rogers, John A.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 49, 04.12.2012, p. 19910-19915.

Research output: Contribution to journalArticle

Kim, DH, Ghaffari, R, Lu, N, Wang, S, Lee, SP, Keum, H, D'Angelo, R, Klinker, L, Su, Y, Lu, C, Kim, YS, Ameen, A, Li, Y, Zhang, Y, De Graff, B, Hsu, YY, Liu, Z, Ruskin, J, Xu, L, Lu, C, Omenetto, FG, Huang, Y, Mansour, M, Slepian, MJ & Rogers, JA 2012, 'Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 49, pp. 19910-19915. https://doi.org/10.1073/pnas.1205923109
Kim, Dae Hyeong ; Ghaffari, Roozbeh ; Lu, Nanshu ; Wang, Shuodao ; Lee, Stephen P. ; Keum, Hohyun ; D'Angelo, Robert ; Klinker, Lauren ; Su, Yewang ; Lu, Chaofeng ; Kim, Yun Soung ; Ameen, Abid ; Li, Yuhang ; Zhang, Yihui ; De Graff, Bassel ; Hsu, Yung Yu ; Liu, ZhuangJian ; Ruskin, Jeremy ; Xu, Lizhi ; Lu, Chi ; Omenetto, Fiorenzo G. ; Huang, Yonggang ; Mansour, Moussa ; Slepian, Marvin J ; Rogers, John A. / Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy. In: Proceedings of the National Academy of Sciences of the United States of America. 2012 ; Vol. 109, No. 49. pp. 19910-19915.
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