Electrophysiological markers of cognitive aging: Region specificity and computational consequences

C. A. Barnes, A. Treves, G. Rao, J. Shen

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A major challenge facing those interested in understanding age-related changes in cognition, is the elucidation of which neurobiological changes contribute significantly to functional loss, and how individual changes make a specific impact on behavior. Functional compensation, preservation and deterioration of cell function have all been observed to occur in senescent hippocampus of memory deficient old animals. The suggestion is made that interpretation of these patterns of brain aging may be greatly facilitated by the use of computational simulation methods directed at the neural networks of interest.

Original languageEnglish (US)
Pages (from-to)359-367
Number of pages9
JournalSeminars in Neuroscience
Volume6
Issue number6
DOIs
StatePublished - Dec 1994

Keywords

  • Aging
  • Hippocampus
  • Neural networks
  • Rats
  • Spatial behavior

ASJC Scopus subject areas

  • Neuroscience(all)

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