Elevated androgen, brain development and language/learning disabilities in children with congenital adrenal hyperplasia

Elena M Plante, Carole Boliek, Anna Binkiewicz, William K. Erly

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Individuals with congenital adrenal hyperplasia (CAH) provide a test population for the theory that elevated testosterone levels alter prenatal brain development and increase the risk of learning disabilities. Eleven subjects with CAH, five of their non-CAH siblings and 16 matched control subjects participated in two studies. The first study documented hand preference, verbal skills and non-verbal skills. A higher prevalence of language/learning disability was found in both the CAH subjects and their families than in the control subjects. The second study examined the prevalence of atypical perisylvian asymmetries on MRI scans. These revealed an atypical pattern of asymmetry (R = L or R > L) in the majority of the subjects with CAH and in all of their siblings. One subject with CAH also showed evidence of a neuromigratory disturbance in the posterior left hemisphere. Of the control subjects, only one showed an atypical pattern of asymmetry and none showed evidence of a neuromigratory disorder. The findings indicate that an elevated familial rate for language-based learning disabilities and altered brain asymmetries co-occur in families with the gene for CAH.

Original languageEnglish (US)
Pages (from-to)423-437
Number of pages15
JournalDevelopmental Medicine and Child Neurology
Volume38
Issue number5
StatePublished - May 1996

Fingerprint

Congenital Adrenal Hyperplasia
Language Development
Learning Disorders
Androgens
Brain
Siblings
Language
Population Dynamics
Hyperplasia
Testosterone
Hand
Cross-Sectional Studies
Magnetic Resonance Imaging
Genes

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neuroscience(all)

Cite this

Elevated androgen, brain development and language/learning disabilities in children with congenital adrenal hyperplasia. / Plante, Elena M; Boliek, Carole; Binkiewicz, Anna; Erly, William K.

In: Developmental Medicine and Child Neurology, Vol. 38, No. 5, 05.1996, p. 423-437.

Research output: Contribution to journalArticle

@article{882fe1b3e14a4e118b4e4129e702f67a,
title = "Elevated androgen, brain development and language/learning disabilities in children with congenital adrenal hyperplasia",
abstract = "Individuals with congenital adrenal hyperplasia (CAH) provide a test population for the theory that elevated testosterone levels alter prenatal brain development and increase the risk of learning disabilities. Eleven subjects with CAH, five of their non-CAH siblings and 16 matched control subjects participated in two studies. The first study documented hand preference, verbal skills and non-verbal skills. A higher prevalence of language/learning disability was found in both the CAH subjects and their families than in the control subjects. The second study examined the prevalence of atypical perisylvian asymmetries on MRI scans. These revealed an atypical pattern of asymmetry (R = L or R > L) in the majority of the subjects with CAH and in all of their siblings. One subject with CAH also showed evidence of a neuromigratory disturbance in the posterior left hemisphere. Of the control subjects, only one showed an atypical pattern of asymmetry and none showed evidence of a neuromigratory disorder. The findings indicate that an elevated familial rate for language-based learning disabilities and altered brain asymmetries co-occur in families with the gene for CAH.",
author = "Plante, {Elena M} and Carole Boliek and Anna Binkiewicz and Erly, {William K.}",
year = "1996",
month = "5",
language = "English (US)",
volume = "38",
pages = "423--437",
journal = "Developmental Medicine and Child Neurology",
issn = "0012-1622",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Elevated androgen, brain development and language/learning disabilities in children with congenital adrenal hyperplasia

AU - Plante, Elena M

AU - Boliek, Carole

AU - Binkiewicz, Anna

AU - Erly, William K.

PY - 1996/5

Y1 - 1996/5

N2 - Individuals with congenital adrenal hyperplasia (CAH) provide a test population for the theory that elevated testosterone levels alter prenatal brain development and increase the risk of learning disabilities. Eleven subjects with CAH, five of their non-CAH siblings and 16 matched control subjects participated in two studies. The first study documented hand preference, verbal skills and non-verbal skills. A higher prevalence of language/learning disability was found in both the CAH subjects and their families than in the control subjects. The second study examined the prevalence of atypical perisylvian asymmetries on MRI scans. These revealed an atypical pattern of asymmetry (R = L or R > L) in the majority of the subjects with CAH and in all of their siblings. One subject with CAH also showed evidence of a neuromigratory disturbance in the posterior left hemisphere. Of the control subjects, only one showed an atypical pattern of asymmetry and none showed evidence of a neuromigratory disorder. The findings indicate that an elevated familial rate for language-based learning disabilities and altered brain asymmetries co-occur in families with the gene for CAH.

AB - Individuals with congenital adrenal hyperplasia (CAH) provide a test population for the theory that elevated testosterone levels alter prenatal brain development and increase the risk of learning disabilities. Eleven subjects with CAH, five of their non-CAH siblings and 16 matched control subjects participated in two studies. The first study documented hand preference, verbal skills and non-verbal skills. A higher prevalence of language/learning disability was found in both the CAH subjects and their families than in the control subjects. The second study examined the prevalence of atypical perisylvian asymmetries on MRI scans. These revealed an atypical pattern of asymmetry (R = L or R > L) in the majority of the subjects with CAH and in all of their siblings. One subject with CAH also showed evidence of a neuromigratory disturbance in the posterior left hemisphere. Of the control subjects, only one showed an atypical pattern of asymmetry and none showed evidence of a neuromigratory disorder. The findings indicate that an elevated familial rate for language-based learning disabilities and altered brain asymmetries co-occur in families with the gene for CAH.

UR - http://www.scopus.com/inward/record.url?scp=0029968141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029968141&partnerID=8YFLogxK

M3 - Article

VL - 38

SP - 423

EP - 437

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

SN - 0012-1622

IS - 5

ER -