Elevated intra-abdominal pressure and renal function

P. K. Harman, I. L. Kron, H. D. McLachlan, A. E. Freedlender, S. P. Nolan

Research output: Contribution to journalArticle

453 Scopus citations

Abstract

The effect of increased intra-abdominal pressure on cardiac output and renal function was investigated using anesthetized dogs into whom intraperitoneal bags were placed. Hemodynamic and renal function measurements were made at intra-abdominal pressures of 0, 20, and 40 mmHg. Renal blood flow and glomerular filtration rate decreased to less than 25% of normal when the intra-abdominal pressure was elevated to 20 mmHg. At 40 mmHg intra-abdominal pressure, three dogs became anuric, and the renal blood flow and glomerular filtration rate of the remaining dogs was 7% of normal, while cardiac output was reduced to 37% of normal. Expansion of the blood volume using Dextran-40 easily corrected the deficit in cardiac output, but renal blood flow and glomerular filtration rate remained less than 25% of normal. Renal vascular resistance increased 555% when the intra-abdominal pressure was elevated from 0 to 20 mmHg, an increase fifteen-fold that of systemic vascular resistance. This suggests that the impairment in renal function produced by increased intra-abdominal pressure is a local phenomenon caused by direct renal compression and is not related to cardiac output.

Original languageEnglish (US)
Pages (from-to)594-597
Number of pages4
JournalUnknown Journal
Volume196
Issue number5
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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    Harman, P. K., Kron, I. L., McLachlan, H. D., Freedlender, A. E., & Nolan, S. P. (1982). Elevated intra-abdominal pressure and renal function. Unknown Journal, 196(5), 594-597. https://doi.org/10.1097/00000658-198211000-00015