Elevation of plasma bromide levels in patients following halothane anesthesia: Time correlation with total halothane dosage

J. H. Tinker, A Jay Gandolfi, R. A. Van Dyke

Research output: Contribution to journalArticle

16 Scopus citations


Plasma bromide concentrations of 25 patients were determined before and after halothane anesthesia. A high correlation (r > .70) between exposure to halothane in MAC hours and plasma bromide levels 24, 48 and 72 hours later was found. Peak bromide levels occurred 48-72 hours after anesthesia in 16 patients (64 per cent), and ranged from 52 μg/ml (0.65 mEq/l) to 180 μq/ml (2.25 mEq/l). Bromide levels remained elevated for prolonged periods (at least 22 days in some patients). Possible sedative or psychoactive effects of increased plasma bromide levels are discussed.

Original languageEnglish (US)
Pages (from-to)194-196
Number of pages3
Issue number3
Publication statusPublished - 1976
Externally publishedYes


ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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