Elicitation of anti-vesicular stomatitis virus cytotoxic T lymphocytes by using purified viral and cellular antigens incorporated into phospholipid vesicles

M. J. Ruebush, A. H. Hale, D. T. Harris

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the minimal molecular and cellular requirements for elicitation of anti-vesicular stomatitis virus (VSV) cytotoxic T lymphocytes (CTL). The results indicated that lipid vesicles containing the purified major surface glycoprotein of VSV (G protein) and purified H-2K(k) glycoproteins elicited specific H-2K(k)-restricted anti-VSV CTL. These antiviral CTL were shown to be Ly 1-, 2+. However, both Ly 1+, 2- and Ly1-, 2+ T-cell subpopulations were shown to be required for elicitation of these CTL.

Original languageEnglish (US)
Pages (from-to)513-517
Number of pages5
JournalInfection and Immunity
Volume32
Issue number2
DOIs
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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