Elicitation of anti-viral cytotoxic T lymphocytes with purified viral and H-2 antigens

A. H. Hale, M. J. Ruebush, D. T. Harris

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The minimal molecular requirements for elicitation of secondary anti-Sendai virus CTL were investigated. The hemagglutinin-neuraminidase (HN) glycoprotein of Sendai virus and the H-2K(k) glycoprotein of YAC tumor cells were purified and incorporated into phospholipid vesicles. These unilamellar liposomes were then tested for the ability to elicit H-2 restricted secondary anti-Sendai virus CTL. The results indicate that these well-defined vesicles were capable of eliciting secondary anti-Sendai virus CTL which lysed only target cells possessing the H-2K(k) haplotype and modifed with inactivated Sendai virus.

Original languageEnglish (US)
Pages (from-to)428-430
Number of pages3
JournalJournal of Immunology
Volume125
Issue number1
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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