Elicitation of specific syntactic structures in primary progressive aphasia

Jessica DeLeon, Benno Gesierich, Max Besbris, Jennifer Ogar, Maya L. Henry, Bruce L. Miller, Maria Luisa Gorno-Tempini, Stephen M. Wilson

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Many patients with primary progressive aphasia (PPA) are impaired in syntactic production. Because most previous studies of expressive syntax in PPA have relied on quantitative analysis of connected speech samples, which is a relatively unconstrained task, it is not well understood which specific syntactic structures are most challenging for these patients. We used an elicited syntactic production task to identify which syntactic structures pose difficulties for 31 patients with three variants of PPA: non-fluent/agrammatic, semantic and logopenic. Neurodegenerative and healthy age-matched participants were included as controls. As expected, non-fluent/agrammatic patients made the most syntactic errors. The structures that resulted in the most errors were constructions involving third person singular present agreement, and constructions involving embedded clauses. Deficits on this elicited production task were associated with atrophy of the left posterior inferior frontal gyrus.

Original languageEnglish (US)
Pages (from-to)183-190
Number of pages8
JournalBrain and Language
Volume123
Issue number3
DOIs
StatePublished - Dec 1 2012

Keywords

  • Primary progressive aphasia
  • Production
  • Syntax
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Language and Linguistics
  • Experimental and Cognitive Psychology
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

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    DeLeon, J., Gesierich, B., Besbris, M., Ogar, J., Henry, M. L., Miller, B. L., Gorno-Tempini, M. L., & Wilson, S. M. (2012). Elicitation of specific syntactic structures in primary progressive aphasia. Brain and Language, 123(3), 183-190. https://doi.org/10.1016/j.bandl.2012.09.004