Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFβ1-deficient mice

Ramireddy Bommireddy, Sandra J. Engle, Ilona Ormsby, Gregory P. Boivin, George F. Babcock, Thomas C Doetschman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Transforming growth factor β1 (TGFβ1) is a potent negative immunoregulatory molecule. We have previously shown that the autoimmune-mediated weaning-age lethality of Tgfb1-/- mice is reversed upon genetic combination with Scid or Rag null alleles. Here, we show that elimination of T but not B cells is sufficient for the reversal, but elimination of either CD4+ or CD8+ cells is not. Although elimination of B cells does not rescue TGFβ1-deficient animals from autoimmunity, B cells are hyperresponsive to LPS in the absence of TGFβ1. TGFβ1 deficiency leads to activation of CD8+ T cells as suggested by down-modulation of CD8 even in the absence of CD4+ T cells. This study provides evidence that both CD4+ and CD8+ T cells, but not B cells, have the ability to cause inflammation in the absence of TGFβ1. However, though TGFβ1-deficient B cells are hyperresponsive to stimulation, alone they are not sufficient to cause inflammation.

Original languageEnglish (US)
Pages (from-to)96-104
Number of pages9
JournalCellular Immunology
Volume232
Issue number1-2
DOIs
StatePublished - Nov 2004
Externally publishedYes

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Transforming Growth Factors
B-Lymphocytes
Inflammation
T-Lymphocytes
Weaning
Autoimmunity
Alleles

Keywords

  • Cell proliferation
  • Growth factors
  • Inflammation
  • Knockout mice
  • T-lymphocytes and B-lymphocytes
  • TGFβ1

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFβ1-deficient mice. / Bommireddy, Ramireddy; Engle, Sandra J.; Ormsby, Ilona; Boivin, Gregory P.; Babcock, George F.; Doetschman, Thomas C.

In: Cellular Immunology, Vol. 232, No. 1-2, 11.2004, p. 96-104.

Research output: Contribution to journalArticle

Bommireddy, Ramireddy ; Engle, Sandra J. ; Ormsby, Ilona ; Boivin, Gregory P. ; Babcock, George F. ; Doetschman, Thomas C. / Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFβ1-deficient mice. In: Cellular Immunology. 2004 ; Vol. 232, No. 1-2. pp. 96-104.
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