Emerging molecular diversity from the intra-molecular Ugi reaction: Iterative efficiency in medicinal chemistry

Christopher Hulme, Justin Dietrich

Research output: Contribution to journalArticle

106 Scopus citations


This review details a now established area within the isonitrile multi-component reaction (IMCR) field of study, namely employing bi-functional reagents in the Ugi reaction for the construction of screening sets with the additional element or even possibly 'metric' of enhanced 'iterative efficiency potential'. The concept of 'iterative efficiency' will be briefly introduced, coupled with discussion on new synthetic routes to select bi-functional IMCR precursors and their use in the generation of pharmacologically relevant 'molecular diversity'.

Original languageEnglish (US)
Pages (from-to)195-207
Number of pages13
JournalMolecular Diversity
Issue number2
Publication statusPublished - May 2009



  • IMCR
  • Iterative efficiency
  • MCR
  • Ugi reaction

ASJC Scopus subject areas

  • Molecular Biology
  • Drug Discovery
  • Information Systems
  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Catalysis
  • Organic Chemistry

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