Emerging molecular diversity from the intra-molecular Ugi reaction: Iterative efficiency in medicinal chemistry

Christopher Hulme, Justin Dietrich

Research output: Contribution to journalReview articlepeer-review

111 Scopus citations

Abstract

This review details a now established area within the isonitrile multi-component reaction (IMCR) field of study, namely employing bi-functional reagents in the Ugi reaction for the construction of screening sets with the additional element or even possibly 'metric' of enhanced 'iterative efficiency potential'. The concept of 'iterative efficiency' will be briefly introduced, coupled with discussion on new synthetic routes to select bi-functional IMCR precursors and their use in the generation of pharmacologically relevant 'molecular diversity'.

Original languageEnglish (US)
Pages (from-to)195-207
Number of pages13
JournalMolecular Diversity
Volume13
Issue number2
DOIs
StatePublished - May 1 2009

Keywords

  • IMCR
  • Iterative efficiency
  • MCR
  • Ugi reaction

ASJC Scopus subject areas

  • Catalysis
  • Information Systems
  • Molecular Biology
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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