Emotional blunting associated with SSRI-induced sexual dysfunction. Do SSRIs inhibit emotional responses?

Adam Opbroek, Pedro L. Delgado, Cindi Laukes, Cindy McGahuey, Joanna Katsanis, Francisco Moreno, Rachel Manber

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Anecdotal and published case reports suggest that some patients taking selective serotonin reuptake inhibitors (SSRI) experience diminution in emotional responsiveness. This study aims to define the individual components of emotion disturbed in these patients. Fifteen patients reporting SSRI-induced sexual dysfunction completed the Laukes Emotional Intensity Scale (LEIS), a questionnaire about various emotions. Compared to controls, patients reported significantly (p < 0.05) less ability to cry, irritation, care about others' feelings, sadness, erotic dreaming, creativity, surprise, anger, expression of their feelings, worry over things or situations, sexual pleasure, and interest in sex. Total score on the LEIS did not correlate with total score on the Hamilton Depression Rating Scale. In our sample, 80% of patients with SSRI-induced sexual dysfunction also describe clinically significant blunting of several emotions. Emotional blunting may be an under-appreciated side-effect of SSRIs that may contribute to treatment non-compliance and/or reduced quality of life.

Original languageEnglish (US)
Pages (from-to)147-151
Number of pages5
JournalInternational Journal of Neuropsychopharmacology
Volume5
Issue number2
DOIs
StatePublished - 2002

Fingerprint

Serotonin Uptake Inhibitors
Emotions
Aptitude
Pleasure
Creativity
Anger
Quality of Life
Depression

Keywords

  • Emotional blunting
  • Sexual dysfunction
  • Side-effect
  • SSRI

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Emotional blunting associated with SSRI-induced sexual dysfunction. Do SSRIs inhibit emotional responses? / Opbroek, Adam; Delgado, Pedro L.; Laukes, Cindi; McGahuey, Cindy; Katsanis, Joanna; Moreno, Francisco; Manber, Rachel.

In: International Journal of Neuropsychopharmacology, Vol. 5, No. 2, 2002, p. 147-151.

Research output: Contribution to journalArticle

Opbroek, Adam ; Delgado, Pedro L. ; Laukes, Cindi ; McGahuey, Cindy ; Katsanis, Joanna ; Moreno, Francisco ; Manber, Rachel. / Emotional blunting associated with SSRI-induced sexual dysfunction. Do SSRIs inhibit emotional responses?. In: International Journal of Neuropsychopharmacology. 2002 ; Vol. 5, No. 2. pp. 147-151.
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