Emotional numbing in posttraumatic stress disorder: A functional magnetic resonance imaging study

Paul A. Frewen, David J A Dozois, Richard W J Neufeld, Richard D Lane, Maria Densmore, Todd K. Stevens, Ruth A. Lanius

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective: To explore the functional neural correlates of emotional numbing symptoms in individuals with posttraumatic stress disorder (PTSD). Method: The study was conducted between September 2006 and June 2008 at the University of Western Ontario. Women with (n = 14) and without (n = 16) PTSD (based on DSM-IV criteria) completed a standardized emotional imagery task while undergoing functional magnetic resonance imaging, in addition to an assessment for emotional numbing symptoms. The study design was correlational, with primary outcome measures being blood oxygenation level-dependent (BOLD) response to emotional imagery task and self-reported severity of emotional numbing symptoms. Women without PTSD were not trauma exposed. Results: In women with PTSD, emotional numbing symptoms predicted less positive affect in response to positive-valence scripts (P < .05) and less BOLD response within the dorsomedial prefrontal cortex during imagery of positive and negative scripts that were explicitly socially relevant (P < .001). In contrast, in women without PTSD, emotional numbing symptoms, while unrelated to subjective emotional responses, predicted greater response within the ventromedial prefrontal cortex during positive and negative scripts, in addition to scripts that elicited fear anxiety by nonsocial means (all P values < .001). The findings could not be attributed to dysphoria. Conclusions: These findings are consistent with previous research regarding emotional numbing and emotional awareness. Less response within the medial prefrontal cortex during emotional imagery in individuals with high emotional numbing may indicate deficient conscious and reflective emotional processing. Further study is required to elucidate associations between state and trait emotional numbing and the neural correlates of psychological treatments specific to emotional numbing.

Original languageEnglish (US)
Pages (from-to)431-436
Number of pages6
JournalJournal of Clinical Psychiatry
Volume73
Issue number4
DOIs
StatePublished - Apr 2012

Fingerprint

Post-Traumatic Stress Disorders
Imagery (Psychotherapy)
Magnetic Resonance Imaging
Prefrontal Cortex
Ontario
Diagnostic and Statistical Manual of Mental Disorders
Fear
Anxiety
Outcome Assessment (Health Care)
Emotion
Functional Magnetic Resonance Imaging
Psychology
Wounds and Injuries
Research
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Arts and Humanities (miscellaneous)

Cite this

Frewen, P. A., Dozois, D. J. A., Neufeld, R. W. J., Lane, R. D., Densmore, M., Stevens, T. K., & Lanius, R. A. (2012). Emotional numbing in posttraumatic stress disorder: A functional magnetic resonance imaging study. Journal of Clinical Psychiatry, 73(4), 431-436. https://doi.org/10.4088/JCP.10m06477

Emotional numbing in posttraumatic stress disorder : A functional magnetic resonance imaging study. / Frewen, Paul A.; Dozois, David J A; Neufeld, Richard W J; Lane, Richard D; Densmore, Maria; Stevens, Todd K.; Lanius, Ruth A.

In: Journal of Clinical Psychiatry, Vol. 73, No. 4, 04.2012, p. 431-436.

Research output: Contribution to journalArticle

Frewen, PA, Dozois, DJA, Neufeld, RWJ, Lane, RD, Densmore, M, Stevens, TK & Lanius, RA 2012, 'Emotional numbing in posttraumatic stress disorder: A functional magnetic resonance imaging study', Journal of Clinical Psychiatry, vol. 73, no. 4, pp. 431-436. https://doi.org/10.4088/JCP.10m06477
Frewen, Paul A. ; Dozois, David J A ; Neufeld, Richard W J ; Lane, Richard D ; Densmore, Maria ; Stevens, Todd K. ; Lanius, Ruth A. / Emotional numbing in posttraumatic stress disorder : A functional magnetic resonance imaging study. In: Journal of Clinical Psychiatry. 2012 ; Vol. 73, No. 4. pp. 431-436.
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