En bloc simultaneous pancreas and kidney allotransplantation in the pig

Rainer W G Gruessner, Periclis J. Tzardis, Richard Schechner, John Heil, Arthur J. Matas, John S. Najarian, David E R Sutherland

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The pig is a large animal suitable for experimental pancreas transplantation due to its anatomy and transplant immunology, both of which are similar to humans. We established a model of en bloc simultaneous pancreas and kidney transplantation that decreases preservation time, operation time, and clamp time. The donor aorta-with celiac axis, superior mesenteric artery, and left renal artery-is anastomosed en bloc to the recipient's aorta in a side-to-oblique fashion. The portal vein is anastomosed end-to-side to the distal vena cava, and the left renal vein end-to-side to the left common iliac vein. The donor duodenum is anastomosed to the bladder to allow monitoring of the urinary amylase for rejection. En bloc transplantation is preferable for separating pancreas and kidney anastomoses in pigs. This technique could be used in humans, especially in adult uremic diabetic patients who receive a combined pancreas/kidney transplant from a pediatric cadaver donor.

Original languageEnglish (US)
Pages (from-to)366-370
Number of pages5
JournalJournal of Surgical Research
Volume49
Issue number4
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Pancreas
Pancreas Transplantation
Swine
Tissue Donors
Kidney
Aorta
Iliac Vein
Transplants
Venae Cavae
Renal Veins
Superior Mesenteric Artery
Renal Artery
Amylases
Portal Vein
Allergy and Immunology
Duodenum
Cadaver
Abdomen
Kidney Transplantation
Anatomy

ASJC Scopus subject areas

  • Surgery

Cite this

Gruessner, R. W. G., Tzardis, P. J., Schechner, R., Heil, J., Matas, A. J., Najarian, J. S., & Sutherland, D. E. R. (1990). En bloc simultaneous pancreas and kidney allotransplantation in the pig. Journal of Surgical Research, 49(4), 366-370. https://doi.org/10.1016/0022-4804(90)90039-5

En bloc simultaneous pancreas and kidney allotransplantation in the pig. / Gruessner, Rainer W G; Tzardis, Periclis J.; Schechner, Richard; Heil, John; Matas, Arthur J.; Najarian, John S.; Sutherland, David E R.

In: Journal of Surgical Research, Vol. 49, No. 4, 1990, p. 366-370.

Research output: Contribution to journalArticle

Gruessner, RWG, Tzardis, PJ, Schechner, R, Heil, J, Matas, AJ, Najarian, JS & Sutherland, DER 1990, 'En bloc simultaneous pancreas and kidney allotransplantation in the pig', Journal of Surgical Research, vol. 49, no. 4, pp. 366-370. https://doi.org/10.1016/0022-4804(90)90039-5
Gruessner, Rainer W G ; Tzardis, Periclis J. ; Schechner, Richard ; Heil, John ; Matas, Arthur J. ; Najarian, John S. ; Sutherland, David E R. / En bloc simultaneous pancreas and kidney allotransplantation in the pig. In: Journal of Surgical Research. 1990 ; Vol. 49, No. 4. pp. 366-370.
@article{575e5b6299f0404e8ae7ace92885e81d,
title = "En bloc simultaneous pancreas and kidney allotransplantation in the pig",
abstract = "The pig is a large animal suitable for experimental pancreas transplantation due to its anatomy and transplant immunology, both of which are similar to humans. We established a model of en bloc simultaneous pancreas and kidney transplantation that decreases preservation time, operation time, and clamp time. The donor aorta-with celiac axis, superior mesenteric artery, and left renal artery-is anastomosed en bloc to the recipient's aorta in a side-to-oblique fashion. The portal vein is anastomosed end-to-side to the distal vena cava, and the left renal vein end-to-side to the left common iliac vein. The donor duodenum is anastomosed to the bladder to allow monitoring of the urinary amylase for rejection. En bloc transplantation is preferable for separating pancreas and kidney anastomoses in pigs. This technique could be used in humans, especially in adult uremic diabetic patients who receive a combined pancreas/kidney transplant from a pediatric cadaver donor.",
author = "Gruessner, {Rainer W G} and Tzardis, {Periclis J.} and Richard Schechner and John Heil and Matas, {Arthur J.} and Najarian, {John S.} and Sutherland, {David E R}",
year = "1990",
doi = "10.1016/0022-4804(90)90039-5",
language = "English (US)",
volume = "49",
pages = "366--370",
journal = "Journal of Surgical Research",
issn = "0022-4804",
publisher = "Academic Press Inc.",
number = "4",

}

TY - JOUR

T1 - En bloc simultaneous pancreas and kidney allotransplantation in the pig

AU - Gruessner, Rainer W G

AU - Tzardis, Periclis J.

AU - Schechner, Richard

AU - Heil, John

AU - Matas, Arthur J.

AU - Najarian, John S.

AU - Sutherland, David E R

PY - 1990

Y1 - 1990

N2 - The pig is a large animal suitable for experimental pancreas transplantation due to its anatomy and transplant immunology, both of which are similar to humans. We established a model of en bloc simultaneous pancreas and kidney transplantation that decreases preservation time, operation time, and clamp time. The donor aorta-with celiac axis, superior mesenteric artery, and left renal artery-is anastomosed en bloc to the recipient's aorta in a side-to-oblique fashion. The portal vein is anastomosed end-to-side to the distal vena cava, and the left renal vein end-to-side to the left common iliac vein. The donor duodenum is anastomosed to the bladder to allow monitoring of the urinary amylase for rejection. En bloc transplantation is preferable for separating pancreas and kidney anastomoses in pigs. This technique could be used in humans, especially in adult uremic diabetic patients who receive a combined pancreas/kidney transplant from a pediatric cadaver donor.

AB - The pig is a large animal suitable for experimental pancreas transplantation due to its anatomy and transplant immunology, both of which are similar to humans. We established a model of en bloc simultaneous pancreas and kidney transplantation that decreases preservation time, operation time, and clamp time. The donor aorta-with celiac axis, superior mesenteric artery, and left renal artery-is anastomosed en bloc to the recipient's aorta in a side-to-oblique fashion. The portal vein is anastomosed end-to-side to the distal vena cava, and the left renal vein end-to-side to the left common iliac vein. The donor duodenum is anastomosed to the bladder to allow monitoring of the urinary amylase for rejection. En bloc transplantation is preferable for separating pancreas and kidney anastomoses in pigs. This technique could be used in humans, especially in adult uremic diabetic patients who receive a combined pancreas/kidney transplant from a pediatric cadaver donor.

UR - http://www.scopus.com/inward/record.url?scp=0025066459&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025066459&partnerID=8YFLogxK

U2 - 10.1016/0022-4804(90)90039-5

DO - 10.1016/0022-4804(90)90039-5

M3 - Article

VL - 49

SP - 366

EP - 370

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 4

ER -