A concise approach for the rapid synthesis of enantiomerically pure α-alkylated derivatives of lactate esters and of other enantiomerically pure α-hydroxy esters is presented. This methodology, which makes use of enantiomeric lithium enolates prepared from diastereomeric tetrahydropyranyl ethers derived from alkyl lactates and other α-hydroxy esters, is used to prepare both enantiomers of frontalin from (S)-(-)-methyl lactate.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 1991|
ASJC Scopus subject areas
- Organic Chemistry