Enantioselective [4 + 2] Cycloaddition Reaction of Vinylquinolines with Dienals Enabled by Synergistic Organocatalysis

Jing Chen, Yiwei Fu, Yang Yu, Jian Rong Wang, Yue Wei Guo, Hao Li, Wei Wang

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

An unprecedented organocatalytic enantioselective [4 + 2] cycloaddition reaction of vinyl quinolines with dienals is achieved with the synergistic activation of CH3SO3H and a chiral aminocatalyst. The power of the process is demonstrated by its high efficiency of the production of new synthetically and biologically valued chiral quinoline architectures in high yields and with excellent enantioselectivities.

Original languageEnglish (US)
Pages (from-to)6061-6066
Number of pages6
JournalOrganic Letters
Volume22
Issue number15
DOIs
StatePublished - Aug 7 2020

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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