Enantioselective conjugate addition of N-heterocycles to α,β-unsaturated ketones catalyzed by chiral primary amines

Guangshun Luo, Shilei Zhang, Wenhu Duan, Wei Wang

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

A new organocatalytic enantioselective conjugate addition reaction of nitrogen-centered heterocycles with α,β-unsaturated ketones has been developed. Promoted by a chiral cinchona alkaloid derived primary amine, the reaction affords the adducts in moderate to high enantioselectivities.

Original languageEnglish (US)
Article numberC00409SS
Pages (from-to)1564-1572
Number of pages9
JournalSynthesis
Issue number9
DOIs
StatePublished - May 2009
Externally publishedYes

Keywords

  • Catalysis
  • Conjugate addition
  • Enones
  • N-heterocycles
  • Primary amines

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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