Abstract
Endogenous retroviruses provide molecular fossils for studying the ancient evolutionary history of retroviruses. Here, we report our independent discovery and analysis of endogenous lentiviral insertions (Mustelidae endogenous lentivirus [MELV]) within the genomes of weasel family (Mustelidae). Genome-scale screening identified MELV elements in the domestic ferret (Mustela putorius furo) genome (MELVmpf). MELVmpf exhibits a typical lentiviral genomic organization. Phylogenetic analyses position MELVmpf basal to either primate lentiviruses or feline immunodeficiency virus. Moreover, we verified the presence of MELV insertions in the genomes of several species of the Lutrinae and Mustelinae subfamilies but not the Martinae subfamily, suggesting that the invasion of MELV into the Mustelidae genomes likely took place between 8.8 and 11.8 Ma. The discovery of MELV in weasel genomes extends the host range of lentiviruses to the Caniformia (order Carnivora) and provides important insights into the prehistoric diversity of lentiviruses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2905-2908 |
| Number of pages | 4 |
| Journal | Molecular Biology and Evolution |
| Volume | 29 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2012 |
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Keywords
- endogenous retrovirus
- lentivirus
- weasel
ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Ecology, Evolution, Behavior and Systematics
Cite this
Endogenous lentiviral elements in the weasel family (mustelidae). / Han, Guan Zhu; Worobey, Michael.
In: Molecular Biology and Evolution, Vol. 29, No. 10, 10.2012, p. 2905-2908.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endogenous lentiviral elements in the weasel family (mustelidae)
AU - Han, Guan Zhu
AU - Worobey, Michael
PY - 2012/10
Y1 - 2012/10
N2 - Endogenous retroviruses provide molecular fossils for studying the ancient evolutionary history of retroviruses. Here, we report our independent discovery and analysis of endogenous lentiviral insertions (Mustelidae endogenous lentivirus [MELV]) within the genomes of weasel family (Mustelidae). Genome-scale screening identified MELV elements in the domestic ferret (Mustela putorius furo) genome (MELVmpf). MELVmpf exhibits a typical lentiviral genomic organization. Phylogenetic analyses position MELVmpf basal to either primate lentiviruses or feline immunodeficiency virus. Moreover, we verified the presence of MELV insertions in the genomes of several species of the Lutrinae and Mustelinae subfamilies but not the Martinae subfamily, suggesting that the invasion of MELV into the Mustelidae genomes likely took place between 8.8 and 11.8 Ma. The discovery of MELV in weasel genomes extends the host range of lentiviruses to the Caniformia (order Carnivora) and provides important insights into the prehistoric diversity of lentiviruses.
AB - Endogenous retroviruses provide molecular fossils for studying the ancient evolutionary history of retroviruses. Here, we report our independent discovery and analysis of endogenous lentiviral insertions (Mustelidae endogenous lentivirus [MELV]) within the genomes of weasel family (Mustelidae). Genome-scale screening identified MELV elements in the domestic ferret (Mustela putorius furo) genome (MELVmpf). MELVmpf exhibits a typical lentiviral genomic organization. Phylogenetic analyses position MELVmpf basal to either primate lentiviruses or feline immunodeficiency virus. Moreover, we verified the presence of MELV insertions in the genomes of several species of the Lutrinae and Mustelinae subfamilies but not the Martinae subfamily, suggesting that the invasion of MELV into the Mustelidae genomes likely took place between 8.8 and 11.8 Ma. The discovery of MELV in weasel genomes extends the host range of lentiviruses to the Caniformia (order Carnivora) and provides important insights into the prehistoric diversity of lentiviruses.
KW - endogenous retrovirus
KW - lentivirus
KW - weasel
UR - http://www.scopus.com/inward/record.url?scp=84864073116&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864073116&partnerID=8YFLogxK
U2 - 10.1093/molbev/mss126
DO - 10.1093/molbev/mss126
M3 - Article
C2 - 22522310
AN - SCOPUS:84864073116
VL - 29
SP - 2905
EP - 2908
JO - Molecular Biology and Evolution
JF - Molecular Biology and Evolution
SN - 0737-4038
IS - 10
ER -