Endogenous peptides for delta opioid receptors and analogues

Victor J. Hruby, Henry I. Mosberg

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

The discovery of the endogenous opioid peptides leucine-enkephalin (H-TyrGly-Gly-Phe-Leu-OH) and methionine-enkephalin (H-Tyr-Gly-Gly-PheMet-OH) [1] (Fig. 1) and the suggestion, first from pharmacological studies [2,3] and later from molecular cloning [4-7], that there are three opioid receptors (mu, delta, and kappa) have had an enormous impact on the search for better opioid analgesics that would not possess the severe toxicities and other undesirable biological activities of the alkaloid morphine and related compounds. The delta opioid receptor, and selective ligands for this receptor that also haveminimal side effects, have been amajor target in opioid research ever since.

Original languageEnglish (US)
Title of host publicationThe Delta Receptor
PublisherCRC Press
Pages159-174
Number of pages16
ISBN (Electronic)9780203025765
ISBN (Print)9780824740313
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Neuroscience(all)
  • Health Professions(all)
  • Medicine(all)

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