Abstract
In this article, the authors briefly review the historical evolution of the various putative precursor lesions for Type II endometrial cancers, with an emphasis on the newly defined "Endometrial Glandular Dysplasia (EmGD)". The evidentiary basis for delineating serous EmGD as the most probable precursor lesions to endometrial serous carcinoma is reviewed in detail. An argument is advanced for the discontinuation of the term serous "endometrial intraepithelial carcinoma (EIC)" as a descriptor for a supposedly intraepithelial, precancerous lesion. Preliminary evidence is also presented that suggests that there is a morphologically recognizable "clear cell EmGD" that probably represents a precancerous lesion to endometrial clear cell carcinomas.
| Original language | English (US) |
|---|---|
| Article number | 6 |
| Journal | Diagnostic Pathology |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2008 |
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ASJC Scopus subject areas
- Histology
- Pathology and Forensic Medicine
Cite this
Endometrial Glandular Dysplasia (EmGD) : Morphologically and biologically distinctive putative precursor lesions of Type II endometrial cancers. / Fadare, Oluwole; Zheng, Wenxin -.
In: Diagnostic Pathology, Vol. 3, No. 1, 6, 2008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endometrial Glandular Dysplasia (EmGD)
T2 - Morphologically and biologically distinctive putative precursor lesions of Type II endometrial cancers
AU - Fadare, Oluwole
AU - Zheng, Wenxin -
PY - 2008
Y1 - 2008
N2 - In this article, the authors briefly review the historical evolution of the various putative precursor lesions for Type II endometrial cancers, with an emphasis on the newly defined "Endometrial Glandular Dysplasia (EmGD)". The evidentiary basis for delineating serous EmGD as the most probable precursor lesions to endometrial serous carcinoma is reviewed in detail. An argument is advanced for the discontinuation of the term serous "endometrial intraepithelial carcinoma (EIC)" as a descriptor for a supposedly intraepithelial, precancerous lesion. Preliminary evidence is also presented that suggests that there is a morphologically recognizable "clear cell EmGD" that probably represents a precancerous lesion to endometrial clear cell carcinomas.
AB - In this article, the authors briefly review the historical evolution of the various putative precursor lesions for Type II endometrial cancers, with an emphasis on the newly defined "Endometrial Glandular Dysplasia (EmGD)". The evidentiary basis for delineating serous EmGD as the most probable precursor lesions to endometrial serous carcinoma is reviewed in detail. An argument is advanced for the discontinuation of the term serous "endometrial intraepithelial carcinoma (EIC)" as a descriptor for a supposedly intraepithelial, precancerous lesion. Preliminary evidence is also presented that suggests that there is a morphologically recognizable "clear cell EmGD" that probably represents a precancerous lesion to endometrial clear cell carcinomas.
UR - http://www.scopus.com/inward/record.url?scp=40749153558&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40749153558&partnerID=8YFLogxK
U2 - 10.1186/1746-1596-3-6
DO - 10.1186/1746-1596-3-6
M3 - Article
C2 - 18261213
AN - SCOPUS:40749153558
VL - 3
JO - Diagnostic Pathology
JF - Diagnostic Pathology
SN - 1746-1596
IS - 1
M1 - 6
ER -