Endometrial Glandular Dysplasia (EmGD): Morphologically and biologically distinctive putative precursor lesions of Type II endometrial cancers

Oluwole Fadare, Wenxin Zheng

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

In this article, the authors briefly review the historical evolution of the various putative precursor lesions for Type II endometrial cancers, with an emphasis on the newly defined "Endometrial Glandular Dysplasia (EmGD)". The evidentiary basis for delineating serous EmGD as the most probable precursor lesions to endometrial serous carcinoma is reviewed in detail. An argument is advanced for the discontinuation of the term serous "endometrial intraepithelial carcinoma (EIC)" as a descriptor for a supposedly intraepithelial, precancerous lesion. Preliminary evidence is also presented that suggests that there is a morphologically recognizable "clear cell EmGD" that probably represents a precancerous lesion to endometrial clear cell carcinomas.

Original languageEnglish (US)
Article number6
JournalDiagnostic Pathology
Volume3
Issue number1
DOIs
StatePublished - Mar 21 2008

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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