Endorphins and the central inhibition of urinary bladder motility

A. Dray, R. Metsch, T. P. Davis

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The involvement of endogenous opioid mechanisms in the central neurogenic control of urinary bladder function has been examined in anesthetized rats. Intracerebroventricular (ICV) microinjection of β-endorphin (0.5-2.0 μg) produced powerful inhibition of rhythmic bladder contractions initiated by central reflex activity. The peptide fragments γ-endorphin and α-endorphin (4-16 μg), formed by the processing of β-endorphin by membrane homogenates of brain, were less active than the parent compound. The inhibitory effects of β-endorphin was reversed by ICV naloxone (1-2 μg) but higher doses were required to reverse γ- or α-endorphin effects. ICV naloxone administered alone increased intravesicular pressure and bladder contraction frequency. These observations support the hypothesis that the endorphins have a physiological role in the central regulation of urinary bladder activity.

Original languageEnglish (US)
Pages (from-to)645-647
Number of pages3
JournalPeptides
Volume5
Issue number3
DOIs
StatePublished - Jan 1 1984

Keywords

  • Bladder motility
  • Central activity
  • Endorphins

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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