Endorphins and the central inhibition of urinary bladder motility

A. Dray, R. Metsch, T. P. Davis

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The involvement of endogenous opioid mechanisms in the central neurogenic control of urinary bladder function has been examined in anesthetized rats. Intracerebroventricular (ICV) microinjection of β-endorphin (0.5-2.0 μg) produced powerful inhibition of rhythmic bladder contractions initiated by central reflex activity. The peptide fragments γ-endorphin and α-endorphin (4-16 μg), formed by the processing of β-endorphin by membrane homogenates of brain, were less active than the parent compound. The inhibitory effects of β-endorphin was reversed by ICV naloxone (1-2 μg) but higher doses were required to reverse γ- or α-endorphin effects. ICV naloxone administered alone increased intravesicular pressure and bladder contraction frequency. These observations support the hypothesis that the endorphins have a physiological role in the central regulation of urinary bladder activity.

Original languageEnglish (US)
Pages (from-to)645-647
Number of pages3
JournalPeptides
Volume5
Issue number3
DOIs
StatePublished - Jan 1 1984

Keywords

  • Bladder motility
  • Central activity
  • Endorphins

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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