Endothelial Cells: The Living Sensors and Actuators

Tzung K. Hsiai, Michael Ing, Juliana Hwang, Adler Salazar, Sung K. Cho, Pak Wang, Chih Ming Ho, Mohamad Navab

Research output: Contribution to journalArticle

Abstract

Cells function as an integral part of living tissues, constantly sensing and responding to biochemical and biomechanical stimuli. Endothelial cells (EC), in particular, are able to discriminate both the temporal and spatial components of shear stress, rending cell signaling, gene expression, and followed by protein formation. We embraced the MEMS technology to characterize real-time shear stress on EC. We provided the first in vitro evidence whereby a distinct pattern of cell-cell binding kinetics developed in parallel with dynamic gene expression in response to oscillatory shear stress.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalInternational Journal of Nonlinear Sciences and Numerical Simulation
Volume3
Issue number3-4
DOIs
StatePublished - Jan 1 2002

Keywords

  • Endothelial cells
  • Gene expression
  • Monocytes
  • Shear stress

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Computational Mechanics
  • Modeling and Simulation
  • Engineering (miscellaneous)
  • Mechanics of Materials
  • Physics and Astronomy(all)
  • Applied Mathematics

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