Endothelial injury and vascular dysfunction associated with the Fogarty balloon catheter

Gary W. Barone, J. Michael Conerly, Patricia C. Farley, Terry L. Flanagan, Irving L. Kron

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Endothelial-derived relaxing factor is an important modulator of vascular relaxation, and its production is very sensitive to endothelial injury. The abdominal aortas of five groups of rabbits were subjected to Fogarty balloon catheterization via the femoral artery. Some rabbits were killed immediately (time 0), and others were killed at weekly intervals. At time 0, isolated vascular rings sectioned from the abdominal aortas and suspended in tissue baths failed to exhibit any endothelial-derived relaxing factor dependent vascular relaxation. Vascular relaxation progressively returned but was not normal until 4 weeks after the initial injury. Morphologic changes studied by means of Evans blue dye and by scanning electron microscopy with silver staining corresponded well with these functional changes. At time 0, the delicate endothelium was completely denuded, but it progressively regenerated over the subsequent 4 weeks. This severe injury to the vascular endothelium and the resultant vascular dysfunction may result in an increased risk of early postoperative spasm and thrombosis after the use of a Fogarty balloon catheter. (J Vasc Surg 1989;9:422–5.)

Original languageEnglish (US)
Pages (from-to)422-425
Number of pages4
JournalJournal of vascular surgery
Volume9
Issue number3
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Vascular System Injuries
Blood Vessels
Catheters
Abdominal Aorta
Balloon Embolectomy
Wounds and Injuries
Rabbits
Evans Blue
Silver Staining
Vascular Endothelium
Spasm
Femoral Artery
Baths
Electron Scanning Microscopy
Endothelium
Thrombosis
Coloring Agents

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Endothelial injury and vascular dysfunction associated with the Fogarty balloon catheter. / Barone, Gary W.; Conerly, J. Michael; Farley, Patricia C.; Flanagan, Terry L.; Kron, Irving L.

In: Journal of vascular surgery, Vol. 9, No. 3, 01.01.1989, p. 422-425.

Research output: Contribution to journalArticle

Barone, Gary W. ; Conerly, J. Michael ; Farley, Patricia C. ; Flanagan, Terry L. ; Kron, Irving L. / Endothelial injury and vascular dysfunction associated with the Fogarty balloon catheter. In: Journal of vascular surgery. 1989 ; Vol. 9, No. 3. pp. 422-425.
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