Endothelin-1 and Endothelin Receptor Gene Variants and Their Association With Negative Outcomes Following Aneurysmal Subarachnoid Hemorrhage

Matthew Gallek, Sheila Alexander, Elizabeth Crago, Paula Sherwood, Michael Horowitz, Samuel Poloyac, Yvette Conley

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating disease that affects approximately 30,000 people a year in the United States. Delayed cerebral ischemia (DCI) and cerebral vasospasm (CV) are common complications after aSAH. In addition, aSAH patients have a high risk of poor long-term outcomes. Endothelin-1 (ET-1), a potent vasoconstrictor, or its two types of receptors, ET receptor A (ETA) and ET receptor B (ETB), may play a role in the pathogenesis of DCI and CV. Genetic variations within the ET-1,ETA, or ETB genes may also account for variance observed in the outcomes of aSAH patients. The purpose of this study was to describe the distribution of the Lys198Asn polymorphism, a known functional SNP in the ET-1 gene, and tagging SNPs of the ET-1, ETA, and ETB genes in individuals recovering from aSAH. This study also investigated the relationships among the ET polymorphisms, DCI, and global functional outcomes measured at 3 and 6 months after aSAH. Participants included individuals aged 18-75 years with a diagnosis of aSAH. There was a trend found between the variant allele of an ET-1 SNP (rs6912834) and angiographic vasospasm. There were also associations found between two ETB SNPs (rs9574124 and rs3027111) and poor outcomes as measured by the Glasgow Outcome scale at 3 months. These findings support the role of ET-1 and ETB in recovery following aSAH.

Original languageEnglish (US)
Pages (from-to)390-397
Number of pages8
JournalBiological research for nursing
Volume15
Issue number4
DOIs
StatePublished - Oct 1 2013

Keywords

  • aneurysmal subarachnoid hemorrhage
  • cerebral vasospasm
  • delayed cerebral ischemia
  • endothelin receptor A
  • endothelin receptor B
  • endothelin-1
  • functional outcomes

ASJC Scopus subject areas

  • Research and Theory

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