Endothelin-1 and Endothelin Receptor Gene Variants and Their Association With Negative Outcomes Following Aneurysmal Subarachnoid Hemorrhage

Matthew J Gallek, Sheila Alexander, Elizabeth Crago, Paula Sherwood, Michael Horowitz, Samuel Poloyac, Yvette Conley

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating disease that affects approximately 30,000 people a year in the United States. Delayed cerebral ischemia (DCI) and cerebral vasospasm (CV) are common complications after aSAH. In addition, aSAH patients have a high risk of poor long-term outcomes. Endothelin-1 (ET-1), a potent vasoconstrictor, or its two types of receptors, ET receptor A (ETA) and ET receptor B (ETB), may play a role in the pathogenesis of DCI and CV. Genetic variations within the ET-1,ETA, or ETB genes may also account for variance observed in the outcomes of aSAH patients. The purpose of this study was to describe the distribution of the Lys198Asn polymorphism, a known functional SNP in the ET-1 gene, and tagging SNPs of the ET-1, ETA, and ETB genes in individuals recovering from aSAH. This study also investigated the relationships among the ET polymorphisms, DCI, and global functional outcomes measured at 3 and 6 months after aSAH. Participants included individuals aged 18-75 years with a diagnosis of aSAH. There was a trend found between the variant allele of an ET-1 SNP (rs6912834) and angiographic vasospasm. There were also associations found between two ETB SNPs (rs9574124 and rs3027111) and poor outcomes as measured by the Glasgow Outcome scale at 3 months. These findings support the role of ET-1 and ETB in recovery following aSAH.

Original languageEnglish (US)
Pages (from-to)390-397
Number of pages8
JournalBiological Research for Nursing
Volume15
Issue number4
DOIs
StatePublished - Oct 2013

Fingerprint

Endothelin A Receptors
Endothelin Receptors
Subarachnoid Hemorrhage
Genes
Single Nucleotide Polymorphism
Endothelin-1
Brain Ischemia
Intracranial Vasospasm
Glasgow Outcome Scale
Vasoconstrictor Agents
Alleles

Keywords

  • aneurysmal subarachnoid hemorrhage
  • cerebral vasospasm
  • delayed cerebral ischemia
  • endothelin receptor A
  • endothelin receptor B
  • endothelin-1
  • functional outcomes

ASJC Scopus subject areas

  • Research and Theory

Cite this

Endothelin-1 and Endothelin Receptor Gene Variants and Their Association With Negative Outcomes Following Aneurysmal Subarachnoid Hemorrhage. / Gallek, Matthew J; Alexander, Sheila; Crago, Elizabeth; Sherwood, Paula; Horowitz, Michael; Poloyac, Samuel; Conley, Yvette.

In: Biological Research for Nursing, Vol. 15, No. 4, 10.2013, p. 390-397.

Research output: Contribution to journalArticle

Gallek, Matthew J ; Alexander, Sheila ; Crago, Elizabeth ; Sherwood, Paula ; Horowitz, Michael ; Poloyac, Samuel ; Conley, Yvette. / Endothelin-1 and Endothelin Receptor Gene Variants and Their Association With Negative Outcomes Following Aneurysmal Subarachnoid Hemorrhage. In: Biological Research for Nursing. 2013 ; Vol. 15, No. 4. pp. 390-397.
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