Endotoxin removal by charge-modified filters

C. P. Gerba, K. Hou

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

The effects of positively charged nylon and depth (cellulose-diatomaceous earth) filters on endotoxin removal from various solutions were evaluated. The charged filter media removed significant amounts of Escherichia coli and natural endotoxin from tap water, distilled water, sugars, and NaCl solutions; no significant removal of endotoxin was observed with negatively charged filter media. The extent of removal was influenced by pH, the presence of salts, and organic matter. Such media may be useful for the control of endotoxins in raw-product water of solutions used to prepare parenteral drug products or in other fluids where endotoxin control is desired.

Original languageEnglish (US)
Pages (from-to)1375-1377
Number of pages3
JournalApplied and environmental microbiology
Volume50
Issue number6
StatePublished - Dec 1 1985

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology
  • Ecology

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