Endotoxin shock elicits greater endorphin secretion than hemorrhage

Allan J Hamilton, D. B. Carr, J. M. LaRovere, P. Black McL.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Opiopeptides may contribute to the pathophysiology of both endotoxic and hemorrhagic shock. To determine if endorphin secretion is similar in both types of shock, we divided 25 sheep into three groups: a saline control group (n = 10), an endotoxin-treated group (n = 9), and a hemorrhage group (n = 6). Each sheep had baseline determinations of mean arterial pressure (MAP) and plasma levels of beta-endorphin-like immunoreactivity (iB-EP). Experimental animals either received endotoxin (450 ng/kg intravenous) or underwent withdrawal of blood volume sufficient to diminish MAP by approximately one-third of baseline values. MAP and iB-EP levels were determined every 15 minutes thereafter for 5 hours. Individual data were averaged within each group and then compared between groups using analysis of variance. Both the endotoxin- and hemorrhage-treated groups showed a significant fall in MAP, which was significantly lower in the hemorrhage group than the endotoxin group. Endotoxin-treated animals displayed a mean peak iB-EP level 1,550% above baseline as compared to a mean peak iB-EP level of only 201% above baseline in the hemorrhage-treated group, despite a significantly greater degree of hypotension in the latter group; this difference in peak iB-EP response was significant. Mean peak iB-EP levels coincided with mean trough MAP values in the endotoxin-treated group while the mean peak iB-EP lagged the onset of mean trough MAP in the hemorrhage group. These results demonstrate that iB-EP secretory patterns differ in endotoxic versus hemorrhagic shock and suggest that distinct mechanisms of opiopeptide secretion accompany the two shock states.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalCirculatory Shock
Volume19
Issue number1
StatePublished - 1986
Externally publishedYes

Fingerprint

Endorphins
Endotoxins
Shock
Arterial Pressure
Hemorrhage
Hemorrhagic Shock
Sheep
beta-Endorphin
Septic Shock
Blood Volume
Hypotension
Analysis of Variance
Control Groups

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hamilton, A. J., Carr, D. B., LaRovere, J. M., & Black McL., P. (1986). Endotoxin shock elicits greater endorphin secretion than hemorrhage. Circulatory Shock, 19(1), 47-54.

Endotoxin shock elicits greater endorphin secretion than hemorrhage. / Hamilton, Allan J; Carr, D. B.; LaRovere, J. M.; Black McL., P.

In: Circulatory Shock, Vol. 19, No. 1, 1986, p. 47-54.

Research output: Contribution to journalArticle

Hamilton, AJ, Carr, DB, LaRovere, JM & Black McL., P 1986, 'Endotoxin shock elicits greater endorphin secretion than hemorrhage', Circulatory Shock, vol. 19, no. 1, pp. 47-54.
Hamilton, Allan J ; Carr, D. B. ; LaRovere, J. M. ; Black McL., P. / Endotoxin shock elicits greater endorphin secretion than hemorrhage. In: Circulatory Shock. 1986 ; Vol. 19, No. 1. pp. 47-54.
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