Abstract
Small doses of endotoxin evoked a dramatic biphasic response of opioid peptide secretion into blood in sheep. The first phase began within minutes and coincided with a brief hypertensive response to endotoxin well before the appearance of fever or hypotension. The ratio of β-endorphin to β-lipotropin fell abruptly at the onset of the second phase of release, suggesting early depletion of a pool rich in β-endorphin and subsequent emergence of a pool rich in unprocessed precursor. The concentration of cerebrospinal fluid opioids increased tenfold during the second phase. Naloxone administration augmented endotoxin-induced opioid secretion in both early and late phases, suggesting a short-loop feedback regulation of stress-induced endorphin secretion.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 845-848 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 217 |
| Issue number | 4562 |
| State | Published - 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
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Cite this
Endotoxin-stimulated opioid peptide secretion : Two secretory pools and feedback control in vivo. / Carr, Daniel B.; Bergland, Richard; Hamilton, Allan J; Blume, Howard; Kasting, Norman; Arnold, Michael; Martin, Joseph B.; Rosenblatt, Michael.
In: Science, Vol. 217, No. 4562, 1982, p. 845-848.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endotoxin-stimulated opioid peptide secretion
T2 - Two secretory pools and feedback control in vivo
AU - Carr, Daniel B.
AU - Bergland, Richard
AU - Hamilton, Allan J
AU - Blume, Howard
AU - Kasting, Norman
AU - Arnold, Michael
AU - Martin, Joseph B.
AU - Rosenblatt, Michael
PY - 1982
Y1 - 1982
N2 - Small doses of endotoxin evoked a dramatic biphasic response of opioid peptide secretion into blood in sheep. The first phase began within minutes and coincided with a brief hypertensive response to endotoxin well before the appearance of fever or hypotension. The ratio of β-endorphin to β-lipotropin fell abruptly at the onset of the second phase of release, suggesting early depletion of a pool rich in β-endorphin and subsequent emergence of a pool rich in unprocessed precursor. The concentration of cerebrospinal fluid opioids increased tenfold during the second phase. Naloxone administration augmented endotoxin-induced opioid secretion in both early and late phases, suggesting a short-loop feedback regulation of stress-induced endorphin secretion.
AB - Small doses of endotoxin evoked a dramatic biphasic response of opioid peptide secretion into blood in sheep. The first phase began within minutes and coincided with a brief hypertensive response to endotoxin well before the appearance of fever or hypotension. The ratio of β-endorphin to β-lipotropin fell abruptly at the onset of the second phase of release, suggesting early depletion of a pool rich in β-endorphin and subsequent emergence of a pool rich in unprocessed precursor. The concentration of cerebrospinal fluid opioids increased tenfold during the second phase. Naloxone administration augmented endotoxin-induced opioid secretion in both early and late phases, suggesting a short-loop feedback regulation of stress-induced endorphin secretion.
UR - http://www.scopus.com/inward/record.url?scp=0019973219&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019973219&partnerID=8YFLogxK
M3 - Article
C2 - 6285473
AN - SCOPUS:0019973219
VL - 217
SP - 845
EP - 848
JO - Science
JF - Science
SN - 0036-8075
IS - 4562
ER -