Endotoxin-stimulated opioid peptide secretion: Two secretory pools and feedback control in vivo

Daniel B. Carr, Richard Bergland, Allan Hamilton, Howard Blume, Norman Kasting, Michael Arnold, Joseph B. Martin, Michael Rosenblatt

Research output: Contribution to journalArticle

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Abstract

Small doses of endotoxin evoked a dramatic biphasic response of opioid peptide secretion into blood in sheep. The first phase began within minutes and coincided with a brief hypertensive response to endotoxin well before the appearance of fever or hypotension. The ratio of β-endorphin to β-lipotropin fell abruptly at the onset of the second phase of release, suggesting early depletion of a pool rich in β-endorphin and subsequent emergence of a pool rich in unprocessed precursor. The concentration of cerebrospinal fluid opioids increased tenfold during the second phase. Naloxone administration augmented endotoxin-induced opioid secretion in both early and late phases, suggesting a short-loop feedback regulation of stress-induced endorphin secretion.

Original languageEnglish (US)
Pages (from-to)845-848
Number of pages4
JournalScience
Volume217
Issue number4562
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Carr, D. B., Bergland, R., Hamilton, A., Blume, H., Kasting, N., Arnold, M., Martin, J. B., & Rosenblatt, M. (1982). Endotoxin-stimulated opioid peptide secretion: Two secretory pools and feedback control in vivo. Science, 217(4562), 845-848. https://doi.org/10.1126/science.6285473