Abstract
Small doses of endotoxin evoked a dramatic biphasic response of opioid peptide secretion into blood in sheep. The first phase began within minutes and coincided with a brief hypertensive response to endotoxin well before the appearance of fever or hypotension. The ratio of β-endorphin to β-lipotropin fell abruptly at the onset of the second phase of release, suggesting early depletion of a pool rich in β-endorphin and subsequent emergence of a pool rich in unprocessed precursor. The concentration of cerebrospinal fluid opioids increased tenfold during the second phase. Naloxone administration augmented endotoxin-induced opioid secretion in both early and late phases, suggesting a short-loop feedback regulation of stress-induced endorphin secretion.
Original language | English (US) |
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Pages (from-to) | 845-848 |
Number of pages | 4 |
Journal | Science |
Volume | 217 |
Issue number | 4562 |
DOIs | |
State | Published - Jan 1 1982 |
Externally published | Yes |
ASJC Scopus subject areas
- General