Endotoxin-stimulated opioid peptide secretion: Two secretory pools and feedback control in vivo

Daniel B. Carr, Richard Bergland, Allan J Hamilton, Howard Blume, Norman Kasting, Michael Arnold, Joseph B. Martin, Michael Rosenblatt

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Small doses of endotoxin evoked a dramatic biphasic response of opioid peptide secretion into blood in sheep. The first phase began within minutes and coincided with a brief hypertensive response to endotoxin well before the appearance of fever or hypotension. The ratio of β-endorphin to β-lipotropin fell abruptly at the onset of the second phase of release, suggesting early depletion of a pool rich in β-endorphin and subsequent emergence of a pool rich in unprocessed precursor. The concentration of cerebrospinal fluid opioids increased tenfold during the second phase. Naloxone administration augmented endotoxin-induced opioid secretion in both early and late phases, suggesting a short-loop feedback regulation of stress-induced endorphin secretion.

Original languageEnglish (US)
Pages (from-to)845-848
Number of pages4
JournalScience
Volume217
Issue number4562
StatePublished - 1982
Externally publishedYes

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Endorphins
Opioid Peptides
Endotoxins
Opioid Analgesics
beta-Lipotropin
Naloxone
Hypotension
Cerebrospinal Fluid
Sheep
Fever

ASJC Scopus subject areas

  • General

Cite this

Carr, D. B., Bergland, R., Hamilton, A. J., Blume, H., Kasting, N., Arnold, M., ... Rosenblatt, M. (1982). Endotoxin-stimulated opioid peptide secretion: Two secretory pools and feedback control in vivo. Science, 217(4562), 845-848.

Endotoxin-stimulated opioid peptide secretion : Two secretory pools and feedback control in vivo. / Carr, Daniel B.; Bergland, Richard; Hamilton, Allan J; Blume, Howard; Kasting, Norman; Arnold, Michael; Martin, Joseph B.; Rosenblatt, Michael.

In: Science, Vol. 217, No. 4562, 1982, p. 845-848.

Research output: Contribution to journalArticle

Carr, DB, Bergland, R, Hamilton, AJ, Blume, H, Kasting, N, Arnold, M, Martin, JB & Rosenblatt, M 1982, 'Endotoxin-stimulated opioid peptide secretion: Two secretory pools and feedback control in vivo', Science, vol. 217, no. 4562, pp. 845-848.
Carr DB, Bergland R, Hamilton AJ, Blume H, Kasting N, Arnold M et al. Endotoxin-stimulated opioid peptide secretion: Two secretory pools and feedback control in vivo. Science. 1982;217(4562):845-848.
Carr, Daniel B. ; Bergland, Richard ; Hamilton, Allan J ; Blume, Howard ; Kasting, Norman ; Arnold, Michael ; Martin, Joseph B. ; Rosenblatt, Michael. / Endotoxin-stimulated opioid peptide secretion : Two secretory pools and feedback control in vivo. In: Science. 1982 ; Vol. 217, No. 4562. pp. 845-848.
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