Enflurane biotransformation in humans

M. S. Miller, A. J. Gandolfi

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The biotransformation of enflurane was investigated in humans. Liquid anion exchange chromatography of extracts of urine obtained during and following enflurane anesthesia revealed the presence of two organic fluoride containing enflurane metabolites. Gas chromatographic-mass spectroscopic analysis of lyophilized urine extracts indicated the presence of 2-difluoromethoxy- 2,2-difluoro-acetic acid. These results suggest that enflurane undergoes both oxidative dechlorination at the β carbon and O-demethylation at the ether linkage in humans.

Original languageEnglish (US)
Pages (from-to)1465-1468
Number of pages4
JournalLife Sciences
Volume27
Issue number16
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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