Enflurane biotransformation in humans

M. S. Miller, A Jay Gandolfi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The biotransformation of enflurane was investigated in humans. Liquid anion exchange chromatography of extracts of urine obtained during and following enflurane anesthesia revealed the presence of two organic fluoride containing enflurane metabolites. Gas chromatography-mass spectroscopic analysis of lyophilized urine extracts indicated the presence of 2-difluoromethoxy- 2,2-difluoro-acetic acid. These results suggest that enflurane undergoes both oxidative dechlorination at the β carbon and O-demethylation at the ether linkage in humans.

Original languageEnglish (US)
Pages (from-to)1465-1468
Number of pages4
JournalLife Sciences
Volume27
Issue number16
DOIs
StatePublished - 1980

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Enflurane
Biotransformation
Urine
Dechlorination
Spectroscopic analysis
Metabolites
Chromatography
Fluorides
Acetic Acid
Gas chromatography
Gas Chromatography
Ether
Anions
Carbon
Anesthesia
Liquids

ASJC Scopus subject areas

  • Pharmacology

Cite this

Enflurane biotransformation in humans. / Miller, M. S.; Gandolfi, A Jay.

In: Life Sciences, Vol. 27, No. 16, 1980, p. 1465-1468.

Research output: Contribution to journalArticle

Miller, M. S. ; Gandolfi, A Jay. / Enflurane biotransformation in humans. In: Life Sciences. 1980 ; Vol. 27, No. 16. pp. 1465-1468.
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