Engineering quadrupole magnetic flow sorting for the isolation of pancreatic islets

David J. Kennedy, Paul Todd, Sam Logan, Matthew Becker, Klearchos K Papas, Lee R. Moore

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Quadrupole magnetic flow sorting (QMS) is being adapted from the separation of suspensions of single cells (<15 μm) to the isolation of pancreatic islets (150-350 μm) for transplant. To achieve this goal, the critical QMS components have been modeled and engineered to optimize the separation process. A flow channel has been designed, manufactured, and tested. The quadrupole magnet assembly has been designed and verified by finite element analysis. Pumps have been selected and verified by test. Test data generated from the pumps and flow channel demonstrate that the fabricated channel and peristaltic pumps fulfill the requirements of successful QMS separation.

Original languageEnglish (US)
Pages (from-to)388-395
Number of pages8
JournalJournal of Magnetism and Magnetic Materials
Volume311
Issue number1 SPEC. ISS.
DOIs
StatePublished - Apr 2007
Externally publishedYes

Fingerprint

classifying
Sorting
isolation
quadrupoles
Pumps
engineering
Channel flow
channel flow
pumps
Transplants
Magnets
Suspensions
Finite element method
magnets
assembly
requirements
cells

Keywords

  • Cell separation
  • Engineering
  • Magnetic separation
  • Pancreatic islets
  • Quadrupole separator
  • Type 1 diabetes

ASJC Scopus subject areas

  • Condensed Matter Physics

Cite this

Engineering quadrupole magnetic flow sorting for the isolation of pancreatic islets. / Kennedy, David J.; Todd, Paul; Logan, Sam; Becker, Matthew; Papas, Klearchos K; Moore, Lee R.

In: Journal of Magnetism and Magnetic Materials, Vol. 311, No. 1 SPEC. ISS., 04.2007, p. 388-395.

Research output: Contribution to journalArticle

Kennedy, David J. ; Todd, Paul ; Logan, Sam ; Becker, Matthew ; Papas, Klearchos K ; Moore, Lee R. / Engineering quadrupole magnetic flow sorting for the isolation of pancreatic islets. In: Journal of Magnetism and Magnetic Materials. 2007 ; Vol. 311, No. 1 SPEC. ISS. pp. 388-395.
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