Engraftment in 86 patients with lymphoid malignancy after autologous marrow transplantation

R. S. Hill, P. Mazza, D. Amos, C. D. Buckner, F. R. Appelbaum, P. Matin, B. J. Still, S. Sica, R. Berenson, W. Bensinger, R. A. Clift, P. Stewart, K. Doney, J. Sanders, J. Singer, K. M. Sullivan, R. P. Whiterspoon, R. Storb, Robert B Livingston

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The kinetics of marrow engraftment was retrospectively analysed in 55 patients with malignant lymphoma (ML) and 31 patients with aucte lymphoblastic leukemia (ALL) after marrow-ablative therapy followed by autologous bone marrow transplantation. Thirty-eight percent of patients with ML, most of whom were transplanted in relapse and 13% of patients with ALL, mostly transplanted in remission, showed failed or delayed engraftment. Analysis of the total patient group showed that failure to recover platelet counts was significantly correlated with detection of disease in the marrow early after transplantation (p < 0.001). Platelet recovery was also correlated with survival (p = 0.0001), disease-free survival (p = 0.0001), and the probability of relapse (p = 0.02). In those patients achieving engraftment, multivariate regression analysis failed to reveal any single in vitro test of marrow nucleated cell or progenitor cell numbers that significantly influenced time to achieve recovery of either granulocyte or platelet counts.

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalBone Marrow Transplantation
Volume4
Issue number1
StatePublished - 1989
Externally publishedYes

Fingerprint

Autologous Transplantation
Bone Marrow
Neoplasms
Platelet Count
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Lymphoma
Recurrence
Bone Marrow Transplantation
Granulocytes
Disease-Free Survival
Stem Cells
Blood Platelets
Multivariate Analysis
Cell Count
Transplantation
Regression Analysis
Survival

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Hill, R. S., Mazza, P., Amos, D., Buckner, C. D., Appelbaum, F. R., Matin, P., ... Livingston, R. B. (1989). Engraftment in 86 patients with lymphoid malignancy after autologous marrow transplantation. Bone Marrow Transplantation, 4(1), 69-74.

Engraftment in 86 patients with lymphoid malignancy after autologous marrow transplantation. / Hill, R. S.; Mazza, P.; Amos, D.; Buckner, C. D.; Appelbaum, F. R.; Matin, P.; Still, B. J.; Sica, S.; Berenson, R.; Bensinger, W.; Clift, R. A.; Stewart, P.; Doney, K.; Sanders, J.; Singer, J.; Sullivan, K. M.; Whiterspoon, R. P.; Storb, R.; Livingston, Robert B.

In: Bone Marrow Transplantation, Vol. 4, No. 1, 1989, p. 69-74.

Research output: Contribution to journalArticle

Hill, RS, Mazza, P, Amos, D, Buckner, CD, Appelbaum, FR, Matin, P, Still, BJ, Sica, S, Berenson, R, Bensinger, W, Clift, RA, Stewart, P, Doney, K, Sanders, J, Singer, J, Sullivan, KM, Whiterspoon, RP, Storb, R & Livingston, RB 1989, 'Engraftment in 86 patients with lymphoid malignancy after autologous marrow transplantation', Bone Marrow Transplantation, vol. 4, no. 1, pp. 69-74.
Hill RS, Mazza P, Amos D, Buckner CD, Appelbaum FR, Matin P et al. Engraftment in 86 patients with lymphoid malignancy after autologous marrow transplantation. Bone Marrow Transplantation. 1989;4(1):69-74.
Hill, R. S. ; Mazza, P. ; Amos, D. ; Buckner, C. D. ; Appelbaum, F. R. ; Matin, P. ; Still, B. J. ; Sica, S. ; Berenson, R. ; Bensinger, W. ; Clift, R. A. ; Stewart, P. ; Doney, K. ; Sanders, J. ; Singer, J. ; Sullivan, K. M. ; Whiterspoon, R. P. ; Storb, R. ; Livingston, Robert B. / Engraftment in 86 patients with lymphoid malignancy after autologous marrow transplantation. In: Bone Marrow Transplantation. 1989 ; Vol. 4, No. 1. pp. 69-74.
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