Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer

Minkyu Kim, Manos Gkikas, Aaron Huang, Jeon Woong Kang, Nisaraporn Suthiwangcharoen, Ramanathan Nagarajan, Bradley D. Olsen

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A simple approach to enhancing the activity and stability of organophosphorus hydrolase (OPH) is developed based on interactions between the hydrophobic poly(propylene oxide) (PPO) block of amphiphilic Pluronics and the enzyme. This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins.

Original languageEnglish (US)
Pages (from-to)5345-5348
Number of pages4
JournalChemical Communications
Volume50
Issue number40
DOIs
StatePublished - May 25 2014
Externally publishedYes

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Aryldialkylphosphatase
Polypropylene oxides
Hydrolases
Poloxamer
Organophosphates
Neurotoxins
Polymers
Enzymes
polypropylene glycol

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Kim, M., Gkikas, M., Huang, A., Kang, J. W., Suthiwangcharoen, N., Nagarajan, R., & Olsen, B. D. (2014). Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer. Chemical Communications, 50(40), 5345-5348. https://doi.org/10.1039/c3cc47675h

Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer. / Kim, Minkyu; Gkikas, Manos; Huang, Aaron; Kang, Jeon Woong; Suthiwangcharoen, Nisaraporn; Nagarajan, Ramanathan; Olsen, Bradley D.

In: Chemical Communications, Vol. 50, No. 40, 25.05.2014, p. 5345-5348.

Research output: Contribution to journalArticle

Kim, M, Gkikas, M, Huang, A, Kang, JW, Suthiwangcharoen, N, Nagarajan, R & Olsen, BD 2014, 'Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer', Chemical Communications, vol. 50, no. 40, pp. 5345-5348. https://doi.org/10.1039/c3cc47675h
Kim, Minkyu ; Gkikas, Manos ; Huang, Aaron ; Kang, Jeon Woong ; Suthiwangcharoen, Nisaraporn ; Nagarajan, Ramanathan ; Olsen, Bradley D. / Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer. In: Chemical Communications. 2014 ; Vol. 50, No. 40. pp. 5345-5348.
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