Enhanced serological and virological findings of epstein-barr virus in patients with aids and aids-related complex

Ciro Valent Sumaya, Richard Neal Boswell, Yasmin Ench, Daniel L. Kisner, Evan M. Hersh, James M. Reuben, Peter W. Peter, Ciro Valent Sumaya, Richard Neal Boswell, Yasmin Ench, Daniel L. Kisner, Evan M. Hersh, James M. Reuben, Peter W. Peter, Ciro Valent Sumaya, Richard Neal Boswell, Yasmin Ench, Daniel L. Kisner, Evan M. Hersh, James M. ReubenPeter W. Peter

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

The potential involvement of Epstein-Barr virus (EBV) in AIDS was examined by determining the type of EBV-specific antibody responses and the EBV content or lymphoprolifer- ative ability present in selected body fluids of patients with AIDS or AIDS-related complex. The results were compared with two control groups. An enhanced antibody response to a broad spectrum of EBV antigens was found in patients with AIDS or AIDS-related complex. The pattern of virus-specific antibody responses resembled that associated with a persistent or reactivated infection. The content of EBV in oropharyngeal secretions and the lymphoproliferative ability in peripheral blood from patients with AIDS or AIDS- related complex was significantly greater than that from healthy controls and approached levels detected in the control group with infectious mononucleosis. These findings, together with recent reports of cellular-level interaction between EBV and human T lympho- tropic virus type III, suggest that EBV may have a contributory role in these disorders.

Original languageEnglish (US)
Pages (from-to)864-870
Number of pages7
JournalJournal of Infectious Diseases
Volume154
Issue number5
DOIs
StatePublished - Nov 1986

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Sumaya, C. V., Boswell, R. N., Ench, Y., Kisner, D. L., Hersh, E. M., Reuben, J. M., Peter, P. W., Sumaya, C. V., Boswell, R. N., Ench, Y., Kisner, D. L., Hersh, E. M., Reuben, J. M., Peter, P. W., Sumaya, C. V., Boswell, R. N., Ench, Y., Kisner, D. L., Hersh, E. M., ... Peter, P. W. (1986). Enhanced serological and virological findings of epstein-barr virus in patients with aids and aids-related complex. Journal of Infectious Diseases, 154(5), 864-870. https://doi.org/10.1093/infdis/154.5.864