Enhanced serological and virological findings of Epstein-Barr virus in patients with AIDS and AIDS-related complex

C. V. Sumaya, R. N. Boswell, Y. Ench, D. L. Kisner, Evan M Hersh, J. M. Reuben, P. W. Mansell

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Abstract

The potential involvement of Epstein-Barr virus (EBV) in AIDS was examined by determining the type of EBV-specific antibody responses and the EBV content or lymphoproliferative ability present in selected body fluids of patients with AIDS or AIDS-related complex. The results were compared with two control groups. An enhanced antibody response to a broad spectrum of EBV antigens was found in patients with AIDS or AIDS-related complex. The pattern of virus-specific antibody responses resembled that associated with a persistent or reactivated infection. The content of EBV in oropharyngeal secretions and the lymphoproliferative ability in peripheral blood from patients with AIDS or AIDS-related complex was significantly greater than that from healthy controls and approached levels detected in the control group with infectious mononucleosis. These findings, together with recent reports of cellular-level interaction between EBV and human T lymphotropic virus type III, suggest that EBV may have a contributory role in these disorders.

Original languageEnglish (US)
Pages (from-to)864-870
Number of pages7
JournalJournal of Infectious Diseases
Volume154
Issue number5
Publication statusPublished - 1986
Externally publishedYes

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Sumaya, C. V., Boswell, R. N., Ench, Y., Kisner, D. L., Hersh, E. M., Reuben, J. M., & Mansell, P. W. (1986). Enhanced serological and virological findings of Epstein-Barr virus in patients with AIDS and AIDS-related complex. Journal of Infectious Diseases, 154(5), 864-870.