Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid

S. Jacob, Erik J Henriksen, A. L. Schiemann, I. Simon, D. E. Clancy, H. J. Tritschler, W. I. Jung, H. J. Augustin, G. J. Dietze

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177 Scopus citations

Abstract

Insulin resistance of skeletal muscle glucose uptake is a prominent feature of Type II diabetes (NIDDM); therefore pharmacological interventions should aim to improve insulin sensitivity. Alpha-lipoic acid (CAS 62-46-4, thioctic acid, ALA), a natural occurring compound frequently used for treatment of diabetic polyneuropathy, enhances glucose utilization in various experimental models. To see whether this compound also augments insulin mediated glucose disposal in NIDDM, 13 patients received either ALA (1000 mg/Thioctacid®/500 ml NaCl, n = 7) or vehicle only (500 ml NaCl, n = 6) during a glucose-clamp study. Both groups were comparable in age, body-mass index and duration of diabetes and had a similar degree of insulin resistance at baseline. Acute parenteral administration of ALA resulted in a significant increase of insulin-stimulated glucose disposal; metabolic clearance rate (MCR) for glucose rose by about 50% (3.76 ml/kg/min = pre vs. 5.82 ml/kg/min = post, p < 0.05), whereas the control group did not show any significant change (3.57 ml/kg/min = pre vs. 3.91 ml/kg/min = post). This is the first clinical study to show that alpha-lipoic acid increases insulin stimulated glucose disposal in NIDDM. The mode of action of ALA and its potential use as an antihyperglycemic agent require further investigation.

Original languageEnglish (US)
Pages (from-to)872-874
Number of pages3
JournalArzneimittel-Forschung/Drug Research
Volume45
Issue number8
Publication statusPublished - 1995
Externally publishedYes

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Keywords

  • alpha-lipoic acid
  • CAS 62-46-4
  • diabetes mellitus, Type II
  • glucose, uptake
  • Thioctacid®, clinical studies

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Jacob, S., Henriksen, E. J., Schiemann, A. L., Simon, I., Clancy, D. E., Tritschler, H. J., ... Dietze, G. J. (1995). Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittel-Forschung/Drug Research, 45(8), 872-874.